Synthesis of some substituted 5H-furo[3,2-g]chromene and benzofuran sulfonate derivatives as potent anti-HIV agents

被引：13

作者：

Amr, A. E. ^{[1
,2
]}

Abdalla, M. M. ^{[3
]}

Essaouy, S. A. ^{[4
]}

Areef, M. M. H. ^{[4
]}

Elgamal, M. H. ^{[2
]}

Nassear, T. A. ^{[4
]}

Haschich, A. E. ^{[4
]}

Al-Omar, M. A. ^{[1
]}

机构：

[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, DEDC, Riyadh 11451, Saudi Arabia

[2] Natl Res Ctr, Appl Organ Chem Dept, Cairo 12622, Egypt

[3] Saco Pharm Co, Res Unit, 6th October City, Egypt

[4] Banha Univ, Dept Organ Chem, Fac Sci, Banha, Egypt

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 07期

关键词：

visnagin; visnagin-9-sulfonyl esters; anti-HIV activities; ANTIMICROBIAL ACTIVITY; NATURAL-PRODUCTS; SCHIFF-BASES; CANDIDATES; DISCOVERY;

D O I：

10.1134/S1070363217070246

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesized visnagin-9-sulfonyl esters underwent cleavage of their pyran ring upon treatment by hydroxylamine hydrochloride, hydrazine hydrate and primary amines. Reaction of visnagin-9-sulfonyl chloride 1 with alcohols or phenol gave the corresponding sulfonate derivatives 2, that were treated with hydroxylamine hydrochloride, anilines or hydrazine derivatives to give the corresponding compounds 3-5, respectively. The obtained products demonstrated potent anti-HIV activity.

引用

页码：1591 / 1600

页数：10

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