Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressings

被引：188

作者：

Borkow, Gadi ^{[1
]}

Gabbay, Jeffrey ^{[1
]}

Dardik, Rima ^{[1
]}

Eidelman, Arthur I. ^{[1
,2
]}

Lavie, Yossi ^{[3
]}

Grunfeld, Yona ^{[3
]}

Ikher, Sergey ^{[4
]}

Huszar, Monica ^{[4
]}

Zatcoff, Richard C. ^{[5
]}

Marikovsky, Moshe ^{[1
]}

机构：

[1] Cupron Sci, Modiin, Israel

[2] Hebrew Univ Jerusalem, Sch Med, Shaare Zedek Med Ctr, IL-91010 Jerusalem, Israel

[3] Harlan Biotech Israel Ltd, Rehovot, Israel

[4] Kaplan Med Ctr, Dept Pathol, Rehovot, Israel

[5] Hillcrest Hosp, Simpsonville, SC USA

来源：

WOUND REPAIR AND REGENERATION | 2010年 / 18卷 / 02期

关键词：

GROWTH-FACTOR; EXPRESSION; ANGIOGENESIS; CERULOPLASMIN; HIF-1-ALPHA; ACTIVATION; SILVER; MICE;

D O I：

10.1111/j.1524-475X.2010.00573.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Copper plays a key role in angiogenesis and in the synthesis and stabilization of extracellular matrix skin proteins, which are critical processes of skin formation. We hypothesized that introducing copper into wound dressings would enhance wound repair. Application of wound dressings containing copper oxide to wounds inflicted in genetically engineered diabetic mice (C57BL/KsOlaHsd-Leprdb) resulted in increased gene and in situ up-regulation of proangiogenic factors (e.g., placental growth factor, hypoxia-inducible factor-1 alpha, and vascular endothelial growth factor), increased blood vessel formation (p < 0.05), and enhanced wound closure (p < 0.01) as compared with control dressings (without copper) or commercial wound dressings containing silver. This study proves the capacity of copper oxide-containing wound dressings to enhance wound healing and sheds light onto the molecular mechanisms by which copper oxide-impregnated dressings stimulate wound healing.

引用

页码：266 / 275

页数：10

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