An Assembled Nanocomplex for Improving both Therapeutic Efficiency and Treatment Depth in Photodynamic Therapy

被引:122
作者
Cao, Hongqian [1 ,2 ]
Wang, Lei [1 ]
Yang, Yang [1 ]
Li, Juan [2 ]
Qi, Yanfei [2 ]
Li, Yue [1 ]
Li, Ying [1 ]
Wang, Hao [1 ]
Li, Junbai [3 ]
机构
[1] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[2] Jilin Univ, Sch Publ Hlth, Changchun 130021, Jilin, Peoples R China
[3] Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
关键词
FRET; hemoglobin; photodynamic therapy; self-assembly; two-photon excitation; GRAPHENE QUANTUM DOTS; 2-PHOTON EXCITATION; CANCER-TREATMENT; OXYGEN CARRIERS; ENERGY-TRANSFER; TUMOR HYPOXIA; NANOPARTICLES; PHOTOSENSITIZERS; RADIOTHERAPY; PORPHYRIN;
D O I
10.1002/anie.201802497
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Photodynamic therapy (PDT) shows unique selectivity and irreversible destruction toward treated tissues or cells, but still has several problems in clinical practice. One is limited therapeutic efficiency, which is attributed to hypoxia in tumor sites. Another is the limited treatment depth because traditional photosensitizes are excited by short wavelength light (<700 nm). An assembled nano-complex system composed of oxygen donor, two-photon absorption (TPA) species, and photosensitizer (PS) was synthesized to address both problems. The photosensitizer is excited indirectly by two-photon laser through intraparticle FRET mechanism for improving treatment depth. The oxygen donor, hemoglobin, can supply extra oxygen into tumor location through targeting effect for enhanced PDT efficiency. The mechanism and PDT effect were verified through both in vitro and in vivo experiments. The simple system is promising to promote two-photon PDT for clinical applications.
引用
收藏
页码:7759 / 7763
页数:5
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