Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice

被引：29

作者：

Gomez-Nicola, Diego ^{[1
,3
]}

Spagnolo, Alessandra ^{[2
]}

Guaza, Carmen ^{[2
]}

Nieto-Sampedro, Manuel ^{[1
,3
]}

机构：

[1] CSIC, Inst Cajal, Neural Plast Grp, Funct & Syst Neurobiol Dept, E-28002 Madrid, Spain

[2] CSIC, Inst Cajal, Neuroimmunol Grp, Funct & Syst Neurobiol Dept, E-28002 Madrid, Spain

[3] Hosp Nacl Paraplej, SESCAM, Expt Neurol Unit, Toledo 45071, Spain

来源：

EXPERIMENTAL NEUROLOGY | 2010年 / 222卷 / 02期

关键词：

CD4; CD8; CX3CR1; Multiple sclerosis; Cytokines; Demyelination; CD8(+) T-CELLS; CHRONIC CONSTRICTION INJURY; MULTIPLE-SCLEROSIS; GROWTH-FACTOR; CEREBROSPINAL-FLUID; REGULATE EXPRESSION; SCIATIC-NERVE; INTERLEUKIN-15; FRACTALKINE; MICROGLIA;

D O I：

10.1016/j.expneurol.2009.12.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IL-15 initially identified as a T proliferating cytokine has several structural and biological similarities with IL-2 and has been associated with a number of autoimmune diseases. Because of the scat-city of information available on the role of IL-15 in MS pathogenesis, we have investigated how the absence of IL-15 affected the development of experimental autoimmune encephalomyelitis, a mouse model of MS Following immunization of IL-15(-/-) and C57BL/6 mice with MOG(35-55), we observed a more severe neurological impairment in the IL-15 knockout mice than in the wild-type group. The enhanced disease severity in IL-15(-/-) mice was associated with greater demyelination in the spinal cord. increased immune cell infiltration and inflammation These events maybe related to the higher CD4/CD8 ratio and the almost absent NK cell activity, congenital immune features of IL-15KO mice Moreover. we found that the fractalkine receptor CX3CR1 was overexpressed in the spinal cord of IL-15(-/-) mice. mainly localized on infiltrating CD8(+) T cells How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated (C) 2010 Elsevier Inc All rights reserved

引用

页码：235 / 242

页数：8

共 46 条

[1] The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease [J].