The role of desmosomes in carcinogenesis

被引：41
|
作者：
Zhou, Guangxin [1 ]
Yang, Linlin [2 ]
Gray, Ashley [3 ]
Srivastava, Amit Kumar [4 ]
Li, Cuiping [5 ]
Zhang, Gongwen [6 ]
Cui, Tiantian [2 ]
机构：
[1] Cent Hosp Binzhou, Binzhou Med Coll, Dept Oncol, Binzhou, Peoples R China
[2] Ohio State Comprehens Canc Ctr, Arthur G James Hosp, Dept Radiat Oncol, 351 Wisemen Hall,410W 12th Ave, Columbus, OH 43210 USA
[3] Ohio State Univ, Columbus, OH 43210 USA
[4] Ohio State Univ, Wexner Med Ctr, Dept Radiol, Div Radiobiol, Columbus, OH 43210 USA
[5] Cent Hosp Binzhou, Binzhou Med Coll, Dept Resp Med, Binzhou, Peoples R China
[6] Cent Hosp Binzhou, Binzhou Med Coll, Dept Cardiac Surg, Binzhou, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2017年 / 10卷
关键词：
desmosome; desmosomal cadherin; beta-catenin; plakoglobin; plakophilins; desmoplakin; HUMAN LUNG-CANCER; SQUAMOUS-CELL CARCINOMA; BETA-CATENIN; ADHESION MOLECULES; PROGNOSTIC MARKER; TUMOR-SUPPRESSOR; DESMOCOLLIN; EXPRESSION; PLAKOPHILIN-1; DESMOPLAKIN;
D O I：
10.2147/OTT.S136367
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression. However, the role of desmosomes in carcinogenesis is still being elucidated. Recent studies revealed that desmosome family members play a crucial role in tumor suppression or tumor promotion. This review focuses on studies that provide insights into the role of desmosomes in carcinogenesis and address their molecular functions.
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页码：4059 / 4063
页数：5
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