Hypoxia and Mucosal Inflammation

被引：107

作者：

Colgan, Sean P. ^{[1
,2
]}

Campbell, Eric L. ^{[1
,2
]}

Kominsky, Douglas J. ^{[2
,3
]}

机构：

[1] Univ Colorado, Sch Med, Dept Med, Aurora, CO 80045 USA

[2] Univ Colorado, Sch Med, Mucosal Inflammat Program, Aurora, CO 80045 USA

[3] Montana State Univ, Dept Microbiol & Immunol, Bozeman, MT 59717 USA

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 | 2016年 / 11卷

关键词：

metabolism; inflammation; creatine; phosphocreatine; nucleotide; nucleoside; nucleotidase; mucosa; colitis; neutrophil; epithelium; murine model; ARYL-HYDROCARBON RECEPTOR; INDUCIBLE FACTOR-I; NEUTROPHIL EXTRACELLULAR TRAPS; COLLAGEN-INDUCED ARTHRITIS; CHAIN FATTY-ACIDS; PROLYL HYDROXYLASE INHIBITION; CHRONIC GRANULOMATOUS-DISEASE; INTESTINAL EPITHELIAL-CELLS; TUMOR-SUPPRESSOR PROTEIN; REGULATORY T-CELLS;

D O I：

10.1146/annurev-pathol-012615-044231

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Sites of inflammation are defined by significant changes in metabolic activity. Recent studies have suggested that O-2 metabolism and hypoxia play a prominent role in inflammation so-called "inflammatory hypoxia," which results from a combination of recruited inflammatory cells (e.g., neutrophils and monocytes), the local proliferation of multiple cell types, and the activation of multiple O-2-consuming enzymes during inflammation. These shifts in energy supply and demand result in localized regions of hypoxia and have revealed the important function off the transcription factor HIF (hypoxia-inducible factor) in the regulation of key target genes that promote inflammatory resolution. Analysis of these pathways has provided multiple opportunities for understanding basic mechanisms of inflammation and has defined new targets for intervention. Here, we review recent work addressing tissue hypoxia and metabolic control of inflammation and immunity.

引用

页码：77 / 100

页数：24

共 172 条

[1] Correlation Between Intraluminal Oxygen Gradient and Radial Partitioning of Intestinal Microbiota [J].

Albenberg, Lindsey ;

Esipova, Tatiana V. ;

Judge, Colleen P. ;

Bittinger, Kyle ;

Chen, Jun ;

Laughlin, Alice ;

Grunberg, Stephanie ;

Baldassano, Robert N. ;

Lewis, James D. ;

Li, Hongzhe ;

Thom, Stephen R. ;

Bushman, Frederic D. ;

Vinogradov, Sergei A. ;

Wu, Gary D. .

GASTROENTEROLOGY, 2014, 147 (05) :1055-+

[2] Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism [J].

Aragones, Julian ;

Schneider, Martin ;

Van Geyte, Katie ;

Fraisl, Peter ;

Dresselaers, Tom ;

Mazzone, Massimiliano ;

Dirkx, Ruud ;

Zacchigna, Serena ;

Lemieux, Helene ;

Jeoung, Nam Ho ;

Lambrechts, Diether ;

Bishop, Tammie ;

Lafuste, Peggy ;

Diez-Juan, Antonio ;

Harten, Sarah K. ;

Van Noten, Pieter ;

De Bock, Katrien ;

Willam, Carsten ;

Tjwa, Marc ;

Grosfeld, Alexandra ;

Navet, Rachel ;

Moons, Lieve ;

Vandendriessche, Thierry ;

Deroose, Christophe ;

Wijeyekoon, Bhathiya ;

Nuyts, Johan ;

Jordan, Benedicte ;

Silasi-Mansat, Robert ;

Lupu, Florea ;

Dewerchin, Mieke ;

Pugh, Chris ;

Salmon, Phil ;

Mortelmans, Luc ;

Gallez, Bernard ;

Gorus, Frans ;

Buyse, Johan ;

Sluse, Francis ;

Harris, Robert A. ;

Gnaiger, Erich ;

Hespel, Peter ;

Van Hecke, Paul ;

Schuit, Frans ;

Van Veldhoven, Paul ;

Ratcliffe, Peter ;

Baes, Myriam ;

Maxwell, Patrick ;

Carmeliet, Peter .

NATURE GENETICS, 2008, 40 (02) :170-180

[3] Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Oshima, Kenshiro ;

Suda, Wataru ;

Nagano, Yuji ;

Nishikawa, Hiroyoshi ;

Fukuda, Shinji ;

Saito, Takuro ;

Narushima, Seiko ;

Hase, Koji ;

Kim, Sangwan ;

Fritz, Joelle V. ;

Wilmes, Paul ;

Ueha, Satoshi ;

Matsushima, Kouji ;

Ohno, Hiroshi ;

Olle, Bernat ;

Sakaguchi, Shimon ;

Taniguchi, Tadatsugu ;

Morita, Hidetoshi ;

Hattori, Masahira ;

Honda, Kenya .

NATURE, 2013, 500 (7461) :232-+

[4] Mitochondrial Gene Polymorphisms That Protect Mice From Colitis [J].

Baer, Florian ;

Bochmann, Wiebke ;

Widok, Andrea ;

Von Medem, Kilian ;

Pagel, Rene ;

Hirose, Misa ;

Yu, Xinhua ;

Kalies, Kathrin ;

Koenig, Peter ;

Boehm, Ruwen ;

Herdegen, Thomas ;

Reinicke, Anna T. ;

Buening, Juergen ;

Lehnert, Hendrik ;

Fellermann, Klaus ;

Ibrahim, Saleh ;

Sina, Christian .

GASTROENTEROLOGY, 2013, 145 (05) :1055-+

[5] Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice [J].

Bishop, Tammie ;

Gallagher, Denis ;

Pascual, Alberto ;

Lygate, Craig A. ;

de Bono, Joseph P. ;

Nicholls, Lynn G. ;

Ortega-Saenz, Patricia ;

Oster, Henrik ;

Wijeyekoon, Bhathiya ;

Sutherland, Andrew I. ;

Grosfeld, Alexandra ;

Aragones, Julian ;

Schneider, Martin ;

van Geyte, Katie ;

Teixeira, Dania ;

Diez-Juan, Antonio ;

Lopez-Barneo, Jose ;

Channon, Keith M. ;

Maxwell, Patrick H. ;

Pugh, Christopher W. ;

Davies, Alun M. ;

Carmeliet, Peter ;

Ratcliffe, Peter J. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (10) :3386-3400

[6] Neddylation-Induced Conformational Control Regulates Cullin RING Ligase Activity In Vivo [J].

Boh, Boon Kim ;

Smith, Peter G. ;

Hagen, Thilo .

JOURNAL OF MOLECULAR BIOLOGY, 2011, 409 (02) :136-145

[7] ENERGY-METABOLISM OF HUMAN-NEUTROPHILS DURING PHAGOCYTOSIS [J].

BORREGAARD, N ;

HERLIN, T .

JOURNAL OF CLINICAL INVESTIGATION, 1982, 70 (03) :550-557

[8] Neutrophil extracellular traps kill bacteria [J].

Brinkmann, V ;

Reichard, U ;

Goosmann, C ;

Fauler, B ;

Uhlemann, Y ;

Weiss, DS ;

Weinrauch, Y ;

Zychlinsky, A .

SCIENCE, 2004, 303 (5663) :1532-1535

[9] Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor [J].

Bruick, RK .

GENES & DEVELOPMENT, 2003, 17 (21) :2614-2623

[10] CLONING OF THE AH-RECEPTOR CDNA REVEALS A DISTINCTIVE LIGAND-ACTIVATED TRANSCRIPTION FACTOR [J].

BURBACH, KM ;

POLAND, A ;

BRADFIELD, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (17) :8185-8189

← 1 2 3 4 5 6 7 8 9 10 →