Optical coherence tomography of the rat cochlea

被引：43
作者：
Wong, BJF
de Boer, JF
Park, BH
Chen, ZP
Nelson, JS
机构：
[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA
[2] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, Orange, CA 92668 USA
[3] Univ Calif Irvine, Ctr Biomed Engn, Henry Samueli Sch Engn, Irvine, CA 92697 USA
[4] Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA
来源：
JOURNAL OF BIOMEDICAL OPTICS | 2000年 / 5卷 / 04期
关键词：
cochlea; ear; optical coherence tomography; low-coherence;
D O I：
10.1117/1.1310165
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Optical coherence tomography (OCT) was used to image the internal structure of a rat cochlea (ex vivo). Immediately following sacrifice, the temporal bone of a Sprague-Dawley rat was harvested. Axial OCT cross sectional images lover regions of interest, 1x1 mm-2x8 mm) were obtained with a spatial resolution of 10-15 mum. The osseous borders of the lateral membranous labyrinth overlying the cochlea and the scala vestibuli, media, and tympani, which were well demarcated by the modiolus, Reissner's and the basilar membranes, were clearly identified. OCT can be used to image internal structures in the cochlea without violating the osseous labyrinth using simple surgical exposure of the promontory, and may potentially be used to diagnose inner ear pathology in vivo in both animal and human subjects labyrinth. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(00)00904-7].
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收藏
页码：367 / 370
页数：4
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