Toxicokinetic-toxicodynamic modelling in an individual based context-Consequences of parameter variability

被引：20

作者：

Ashauer, Roman ^{[1
]}

机构：

[1] Eawag, Swiss Fed Inst Aquat Sci & Technol, Dept Environm Toxicol, CH-8600 Dubendorf, Switzerland

来源：

ECOLOGICAL MODELLING | 2010年 / 221卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

Mechanistic effect models; Survival; Ecotoxicology; Individual tolerance; Hazard models; Individual based model; Heterogeneity; Pulsed exposure; INVERTEBRATES; PESTICIDES; DYNAMICS; EXPOSURE;

D O I：

10.1016/j.ecolmodel.2010.01.015

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

Toxicokinetic-toxicodynamic (TKTD) models simulate the time-course of toxicant concentration in the organism and toxicity at the level of the organism. A link between TKTD models that simulate survival and individual based models for populations (IBMs) is proposed which allows TKTD parameters to vary between individuals. The TKTD-IBM predicts different survival in response to toxicants when TKTD parameters vary amongst individuals compared to the survival predicted with fixed TKTD parameters. The model with fixed parameters represents the concept of stochastic death whereas the model with variable parameters behaves, at least partly, according to the individual tolerance distribution concept. The whole set of TKTD parameters of an individual can be interpreted as constituting "individual tolerance". (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1325 / 1328

页数：4

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