Abrogation of the Interferon Response Promotes More Efficient Human Cytomegalovirus Replication

被引：14

作者：

McSharry, Brian P. ^{[1
]}

Forbes, Simone K. ^{[1
,2
]}

Avdic, Selmir ^{[1
]}

Randall, Richard E. ^{[3
]}

Wilkinson, Gavin W. G. ^{[4
]}

Abendroth, Allison ^{[1
]}

Slobedman, Barry ^{[1
]}

机构：

[1] Univ Sydney, Discipline Infect Dis & Immunol, Sydney Med Sch, Camperdown, NSW, Australia

[2] Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW, Australia

[3] Univ St Andrews, Sch Biol, St Andrews, Fife, Scotland

[4] Cardiff Univ, Sch Med, Dept Med Microbiol, Cardiff Inst Infect & Immun, Cardiff CF10 3AX, S Glam, Wales

来源：

JOURNAL OF VIROLOGY | 2015年 / 89卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

SIMPLEX-VIRUS TYPE-1; I INTERFERON; ALPHA/BETA-INTERFERON; REGULATORY FACTOR-3; ANTIVIRAL RESPONSE; GAMMA-INTERFERON; GENE-EXPRESSION; BETA-INTERFERON; CELL FUNCTION; BINDING;

D O I：

10.1128/JVI.02988-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling HCMV replication and provide useful tools to investigate the IFN response to HCMV.

引用

页码：1479 / 1483

页数：5

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