Reduction of radiotherapy-induced late complications in early breast cancer: The role of intensity-modulated radiation therapy and partial breast irradiation - Part I - Normal tissue complications

被引:29
作者
Coles, CE [1 ]
Moody, AM [1 ]
Wilson, CB [1 ]
Burnet, NG [1 ]
机构
[1] Addenbrookes Hosp, Oncol Ctr, Cambridge CB2 2QQ, England
关键词
breast cancer; late normal tissue complications; radiotherapy;
D O I
10.1016/j.clon.2004.08.008
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiotherapy after conservation surgery has been proven to decrease local relapse and death from breast cancer, and is now firmly established in the management of early breast carcinoma. Currently, the challenge is to minimise the morbidity caused by this treatment without losing its efficacy. This review will be divided into two parts, with Part I focusing on the radiation factors contributing to late normal tissue complications after radiotherapy for early breast cancer. Three major normal tissue side-effects will be discussed: cosmetic outcome, cardiac complications and pulmonary side-effects. (C) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:16 / 24
页数:9
相关论文
共 72 条
[1]   COSMETIC RESULTS AFTER SURGERY, CHEMOTHERAPY, AND RADIATION-THERAPY FOR EARLY BREAST-CANCER [J].
ABNER, AL ;
RECHT, A ;
VICINI, FA ;
SILVER, B ;
HAYES, D ;
COME, S ;
HARRIS, JR .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 21 (02) :331-338
[2]   The cosmetic outcome in early breast cancer treated with breast conservation [J].
Al-Ghazal, SK ;
Blamey, RW ;
Stewart, J ;
Morgan, DAL .
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1999, 25 (06) :566-570
[3]   Does cosmetic outcome from treatment of primary breast cancer influence psychosocial morbidity? [J].
Al-Ghazal, SK ;
Fallowfield, L ;
Blamey, RW .
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1999, 25 (06) :571-573
[4]   Does variability in normal tissue reactions after radiotherapy have a genetic basis - where and how to look for it? [J].
Andreassen, CN ;
Alsner, J ;
Overgaard, J .
RADIOTHERAPY AND ONCOLOGY, 2002, 64 (02) :131-140
[5]   PATHOPHYSIOLOGY OF IRRADIATED SKIN AND BREAST [J].
ARCHAMBEAU, JO ;
PEZNER, R ;
WASSERMAN, T .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 31 (05) :1171-1185
[6]  
Ash D V, 1995, Clin Oncol (R Coll Radiol), V7, P93, DOI 10.1016/S0936-6555(05)80808-8
[7]  
Azria D, 2003, BREAST CANCER RES TR, V82, pS183
[8]  
BARCELLOSHOFF MH, 1995, 10 INT C RAD RES WUR, P761
[9]   Commentary on the paper "A preliminary report of intraoperative radiotherapy (IORT) in limited-stage breast cancers that are conservatively treated". A critical review of an innovative approach [J].
Bartelink, H .
EUROPEAN JOURNAL OF CANCER, 2001, 37 (17) :2143-2146
[10]  
Bentzen, 1994, Semin Radiat Oncol, V4, P68, DOI 10.1016/S1053-4296(05)80034-7