Utility of Routine Laboratory Biomarkers to Detect COVID-19: A Systematic Review and Meta-Analysis

被引：5

作者：

Suklan, Jana ^{[1
]}

Cheaveau, James ^{[2
]}

Hill, Sarah ^{[3
]}

Urwin, Samuel G. ^{[4
]}

Green, Kile ^{[1
]}

Winter, Amanda ^{[4
]}

Hicks, Timothy ^{[4
]}

Boath, Anna E. ^{[3
]}

Kernohan, Ashleigh ^{[3
]}

Price, D. Ashley ^{[1
,2
,4
]}

Allen, A. Joy ^{[1
]}

Moloney, Eoin ^{[3
]}

Graziadio, Sara ^{[4
]}

机构：

[1] Newcastle Univ, NIHR Newcastle In Vitro Diagnost Cooperat, Translat & Clin Res Inst, Med Sch, William Leech Bldg, Newcastle NE2 4HH, England

[2] Newcastle Upon Tyne Hosp NHS Fdn Trust, Royal Victoria Infirm, Dept Infect Dis, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[3] Newcastle Univ, Fac Med Sci, Populat Hlth Sci Inst, Hlth Econ Grp, Baddiley Clark Bldg, Newcastle Upon Tyne NE2 4AX, Tyne & Wear, England

[4] Newcastle Upon Tyne Hosp NHS Fdn Trust, NIHR Newcastle In Vitro Diagnost Cooperat, Med Sch, William Leech Bldg, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 05期

关键词：

systematic review; meta-analysis; COVID-19; diagnosis; biomarker;

D O I：

10.3390/v13050803

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

No routine laboratory biomarkers perform well enough in diagnosing COVID-19 in isolation for them to be used as a standalone diagnostic test or to help clinicians prioritize patients for treatment. Instead, other diagnostic tests are needed. The aim of this work was to statistically summarise routine laboratory biomarker measurements in COVID-19-positive and -negative patients to inform future work. A systematic literature review and meta-analysis were performed. The search included names of commonly used, routine laboratory tests in the UK NHS, and focused on research papers reporting laboratory results of patients diagnosed with COVID-19. A random effects meta-analysis of the standardized mean difference between COVID-19-positive and -negative groups was conducted for each biomarker. When comparing reported laboratory biomarker results, we identified decreased white blood cell, neutrophil, lymphocyte, eosinophil, and platelet counts; while lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase were elevated in COVID-19-positive compared to COVID-19-negative patients. Differences were identified across a number of routine laboratory biomarkers between COVID-19-positive and -negative patients. Further research is required to identify whether routine laboratory biomarkers can be used in the development of a clinical scoring system to aid with triage of patients.

引用

页数：11