A one-pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents

被引：23

作者：

Desai, Nisheeth C. ^{[1
]}

Joshi, Surbhi B. ^{[1
]}

Jadeja, Krunalsinh A. ^{[1
]}

机构：

[1] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem DST FIST Sponsored & UGC NON SAP, Div Med Chem, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 02期

关键词：

BIOLOGICAL EVALUATION; PYRAZOLE; GREEN; CHLOROTRIMETHYLSILANE;

D O I：

10.1002/jhet.3821

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of pyrimidinthiones was carried out in presence of thiourea and easily available catalyst sulfamic acid (2a-t). One-pot Biginelli reaction is very important due to the use of simple and readily available chemicals, less reaction time, economically friendly, and furnishing good yield. Structures of the synthesized compounds are characterized by spectral techniques like IR, H-1-NMR, C-13-NMR, and LC-MS. Synthesized compounds were studied for their antimicrobial activity against several strains of bacteria (E. coli, P. aeruginosa, and S. aureus, S. pyogenes) and fungi (C. albicans, A. niger, and A. clavatus) using serial dilution method.

引用

页码：791 / 795

页数：5

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