Synthesis and anticancer effect of chrysin derivatives

被引：184
作者：
Zheng, X
Meng, WD
Xu, YY
Cao, JG
Qing, FL
机构：
[1] Donghua Univ, Coll Chem & Chem Engn, Shanghai 200051, Peoples R China
[2] Nanhua Univ, Inst Canc Res, Hengyang 421001, Hunan, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 05期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/S0960-894X(02)01081-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of chrysin derivatives, prepared by alkylation, halogenation, nitration, methylation, acetylation and trifluoromethylation, were tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and colorectal adenocarcinoma (HT-29) cells. Among these derivatives of chrysin, 5,7-dimethoxy-8-iodochrysin 3 and 8-bromo-5-hydroxy-7-methoxychrysin 11 have the strongest activities against SGC-7901 and HT-29 cells, respectively. 5,7-Dihydroxy-8-nitrochrysin 12 were found to have strong activities against both SGC-7901 and HT-29 cells. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：881 / 884
页数：4
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