Long noncoding RNA-miRNA-mRNA axes multiple roles in osteosarcoma

被引：4

作者：

Malakoti, Faezeh ^{[1
,2
]}

Alemi, Forough ^{[1
]}

Karimzadeh, Haniye ^{[3
,4
]}

Asemi, Zatollah ^{[5
]}

Asadi, Milad ^{[6
]}

Ghobadi, Hadi ^{[1
]}

Soleimanpour, Jafar ^{[7
]}

Yousefi, Bahman ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Dept Biochem & Clin Labs, Fac Med, Tabriz, Iran

[2] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran

[3] Isfahan Univ Med Sci, Sch Pharm, Dept Clin Biochem, Esfahan, Iran

[4] Isfahan Univ Med Sci, Isfahan Pharmaceut Sci Res Ctr, Esfahan, Iran

[5] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

[6] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[7] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran

来源：

GENE REPORTS | 2021年 / 23卷

关键词：

lncRNA; Osteosarcoma; Cancer diagnosis; Signaling pathway; Gene therapy; PROMOTES CELL-PROLIFERATION; ADENOCARCINOMA TRANSCRIPT 1; POOR-PROGNOSIS; INHIBITS PROLIFERATION; SIGNALING PATHWAY; MALAT1; PROMOTES; DOWN-REGULATION; UP-REGULATION; METASTASIS; PROGRESSION;

D O I：

10.1016/j.genrep.2021.101090

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Osteosarcoma is the most predominant primary bone malignant tumor in adolescents, characterized by high tumor mortality and poor treatment ratio. Long noncoding RNAs (lncRNAs) have important roles in key cell biological events encompassing differentiation, proliferation, development, invasion, and migration which accomplish this task by regulating genome functions including transcription, splicing, and epigenetics. Besides, some lncRNAs have been recently connected with the emergence of malignancy, and also important events involved in the cancer treatment process, such as drug sensitivity and resistance. In this article, we reviewed the effects of lncRNAs on osteosarcoma cells progression, prognosis, and drug resistance by modulating miRNAs and signaling pathways.

引用

页数：10

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