Liquid Biopsy and Lung Cancer

被引：97

作者：

Pisapia, Pasquale ^{[1
]}

Malapelle, Umberto ^{[1
]}

Troncone, Giancarlo ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Publ Hlth, Via S Pansini 5, IT-80131 Naples, Italy

来源：

ACTA CYTOLOGICA | 2019年 / 63卷 / 06期

关键词：

Non-small cell lung cancer; Lung cancer; Personalized medicine; Liquid biopsy; Circulating tumor DNA; Quantitative polymerase chain reaction; Digital polymerase chain reaction; Next generation sequencing; EGFR; CELL-FREE DNA; CIRCULATING FREE DNA; FACTOR RECEPTOR MUTATIONS; FREE-TUMOR-DNA; EGFR MUTATIONS; OPEN-LABEL; DIGITAL PCR; PHASE-III; GEFITINIB; PLASMA;

D O I：

10.1159/000492710

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The identification of non-small cell lung cancer (NSCLC) patients potentially responsive to targeted therapies relies on a number of relevant biomarkers, including EGFR, ALK, ROS-1, and PD-L1. Biomarker identification is most commonly based on surgical sample collection. However, when tissues are difficult to reach or when multiple analyses are necessary to monitor tumor progression and treatment response, liquid biopsy is a valid noninvasive alternative. This analysis, which is preferentially performed on circulating tumor DNA (ctDNA) extracted from plasma samples, has the major advantage of reducing the inherent risks and discomfort of tissue biopsy. However, a major disadvantage is that it yields only a low number of ctDNA targets. Thus, to avoid false-positive and false-negative results, it is important to adopt and validate technologies with high sensitivity and specificity in the pre-analytical phase of sampling. This review succinctly addresses the principal methodologies for analyzing plasma-derived ctDNA in NSCLC patients.

引用

页码：489 / 496

页数：8

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