Ribosome-inactivating proteins depurinate poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase and have transforming activity for 3T3 fibroblasts

被引：41

作者：

Barbieri, L ^{[1
]}

Brigotti, M ^{[1
]}

Perocco, P ^{[1
]}

Carnicelli, D ^{[1
]}

Ciani, M ^{[1
]}

Mercatali, L ^{[1
]}

Stirpe, F ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Patol Sperimentale, I-40126 Bologna, Italy

来源：

FEBS LETTERS | 2003年 / 538卷 / 1-3期

关键词：

ribosome-inactivating protein; poly(ADP-ribose) polymerase; adenine polynucleotide glycosylase; cell transformation;

D O I：

10.1016/S0014-5793(03)00176-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been known that ribosome-inactivating proteins (RIPs) from plants damage ribosomes by removing adenine from a precise position of rRNA. Subsequently it was observed that all tested RIPs depurinate DNA, and some of them also non-ribosomal RNAs and poly(A), hence the denomination of adenine polynucleotide glycosylases was proposed. We report now that ricin, saporin-L2, saporin-S6, gelonin and momordin depurinate also poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase (auto modified enzyme), an enzyme involved in DNA repair. We observed also that all RIPs but gelonin induce transformation of fibroblasts, possibly as a consequence of damage to DNA and of the altered DNA repair system. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：178 / 182

页数：5

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