Relationship between high sensitivity troponins and estimated glomerular filtration rate

Background: Diagnosis of acute coronary syndrome way be challenging because of high troponin concentrations in patients with chronic kidney disease. Objective: the aim of this study is to investigate the difference between high sensitivity troponin T and troponin I in four groups of patients separated according to eGFR values and the effect of renal function both on troponin T and troponin I. Methods: 119 outpatients were divided into 4 groups according to their eGFR values as Group 1: eGFR < 30, Group 2: eGFR between 30 and 60, Group 3: eGFR between 60 and 90 and Group 4: eGFR N90 mL/min/1.73 m(2). The cardiac troponin T and I concentrations were measured concurrently. Results: Troponin T values of all patients who have eGFR values lower than 30 mL/min/1.73 m2 were above the decision point, but cTnI values of only 2 patients were above the decision limit (40 ng/L) in this group. There was a strong and significant negative relationship between eGFR and hs-cTnT [log(y) = 2.3 - 0.72log(x); R-2 = 0.625] whereas there was no significant relationship between eGFR and hs-cTnI [log(y) = 1.28 - 0.08log(x); R-2 = 0.013] when eGFR was taken into consideration as a continuous variable. Conclusion: In this study, we found that cTnT increases with decreasing eGFR values, but cTnI is not affected by the change in eGFR values. (C) 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.