Minor Nortriterpenoids from the Twigs and Leaves of Rhododendron latoucheae

被引：20

作者：

Liu, Fei ^{[1
]}

Wang, Ya-Nan ^{[1
]}

Li, Yong ^{[1
]}

Ma, Shuang-Gang ^{[1
]}

Qu, Jing ^{[1
]}

Liu, Yun-Bao ^{[1
]}

Niu, Chang-Shan ^{[1
]}

Tang, Zhong-Hai ^{[1
]}

Li, Yu-Huan ^{[2
,3
]}

Li, Li ^{[1
]}

Yu, Shi-Shan ^{[1
]}

机构：

[1] Chinese Acad Med Sci, State Key Lab Bioact Substance & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 08期

基金：

中国国家自然科学基金;

关键词：

HRMS-SPE-NMR; LC-MS; PENTACYCLIC TRITERPENOIDS; ALPHA-GLUCOSIDASE; NATURAL-PRODUCTS; CRUDE EXTRACT; IDENTIFICATION; CONSTITUENTS; INHIBITORS; SKELETON;

D O I：

10.1021/acs.jnatprod.7b01074

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A hyphenated NMR technique (analytical HPLC with a DAD connected to MS, SPE, and NMR) has proven effective for the full structural analysis and identification of minor natural products in complex mixtures. Application of this hyphenated technique to the CH2Cl2-soluble fraction of Rhododendron latoucheae led to the identification of 15 new minor ursane-type 28-nortriterpenoids (1-15). Compounds 1 and 12 inhibited HSV-1 with IC50 values of 6.4 and 0.4 mu M, respectively.

引用

页码：1721 / 1733

页数：13

共 37 条

[1] Inhibitory effects of lupene-derived pentacyclic triterpenoids from Bursera simaruba on HSV-1 and HSV-2 in vitro replication [J].