Anti-GM1 antibody facilitates leakage in an in vitro blood-nerve barrier model

被引：31

作者：

Kanda, T

Iwasaki, T

Yamawaki, M

Tai, T

Mizusawa, H

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med, Dept Neurol & Neurosci, Bunkyo Ku, Tokyo 1138519, Japan

[2] Tokyo Metropolitan Inst Med Sci, Dept Tumor Immunol, Tokyo, Japan

来源：

NEUROLOGY | 2000年 / 55卷 / 04期

关键词：

D O I：

10.1212/WNL.55.4.585

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using an in vitro blood-nerve barrier (BNB) model, the authors tested the effect of various monoclonal antiganglioside antibodies on BNB function. Only anti-GM1 antibody significantly facilitated BNB leakage in a concentration-dependent, complement-independent manner. This study provided evidence that anti-GM1 antibody, frequently detected in sera from patients with inflammatory neuropathies, may participate BNB dysfunction and contribute to development of neuropathy.

引用

页码：585 / 587

页数：3

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