Hemoglobin A1C assays and hemoglobinopathies:: problems and strategies

被引：0
|
作者：
Gillery, P
Hue, G
Bordas-Fonfrède, M
Chapelle, JP
Drouin, P
Lévy-Marchal, C
Périer, C
Sélam, JL
Slama, G
Thivolet, C
Vialettes, B
机构：
[1] CHU Reims, Hop Robert Debre, Lab Cent Biochim, Reims, France
[2] CHU Rouen, Hop Charles Nicolle, Lab Biochim Med, Rouen, France
[3] Grp Hosp Pitie Salpetriere, Dept Biol Clin, F-75634 Paris, France
[4] CHU Nancy, Hop Jeanne Arc, Serv Med G, Nancy, France
[5] Hop Robert Debre, Serv Endocrinol Diabetol Pediat, F-75019 Paris, France
[6] CHU St Etienne, Lab Biochim, St Etienne, France
[7] Hop Hotel Dieu, Serv Diabetol, Paris, France
[8] Hop Edouard Herriot, Serv Endocrinol Diabet Nutr, Lyon, France
[9] CHU Marseille, Hop St Marguerite, Serv Nutr, Marseille, France
来源：
ANNALES DE BIOLOGIE CLINIQUE | 2000年 / 58卷 / 04期
关键词：
HbA(1C); hemoglobinopathies; assays; interferences; diabetes mellitus;
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The semiological Value of hemoglobin A(1c) (HbA(1c)) as a retrospective and cumulative marker of glycemic balance in diabetic patients is greatly weakened in case of hemoglobinopathy. The presence of an abnormal hemoglobin raises methodological problems due to the interferences generated in most assay methods, but also alters the normal process of HbA glycation to HbA(1c), and often induces a certain level of hemolysis, very variable and impossible to quantify. This paper reviews methodological and semiological problems related to the presence of abnormal hemoglobin species, and proposes a standardized strategy in case of hemoglobinopathies.
引用
收藏
页码：425 / 429
页数：5
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