Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an Oriental herbal medicine

被引：137

作者：

Maruyama, Y

Kuribara, H

Morita, M

Yuzurihara, M

Weintraub, ST

机构：

[1] Gunma Univ, Sch Med, Dept Neuropsychopharmacol, Maebashi, Gumma 371, Japan

[2] Gunma Univ, Sch Med, Dept Neurobiol & Behav, Behav Res Inst, Maebashi, Gumma 371, Japan

[3] Tsumura & Co, Cent Res Labs, Ibaraki, Osaka 30011, Japan

[4] Univ Texas, Hlth Sci Ctr, Dept Biochem, San Antonio, TX 78284 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期

关键词：

D O I：

10.1021/np9702446

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2-propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1, 1'-biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.

引用

页码：135 / 138

页数：4

共 12 条

[1] USE OF THE ELEVATED PLUS-MAZE IN THE SEARCH FOR NOVEL ANXIOLYTIC AGENTS [J].