Paclitaxel-loaded polymeric depots as injectable drug delivery system for cancer chemotherapy of hepatocellular carcinoma

被引：11
作者：
Nasongkla, Norased [1 ]
Nittayacharn, Pinunta [1 ]
Rotjanasitthikit, Apichada [1 ]
Pungbangkadee, Korawich [1 ]
Manaspon, Chawan [1 ]
机构：
[1] Mahidol Univ, Dept Biomed Engn, Fac Engn, 25-25 Puttamonthon 4th Rd, Nakhon Pathom 73170, Thailand
来源：
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2017年 / 22卷 / 05期
关键词：
Biodegradable polymers; drug delivery system; paclitaxel; polymeric depot; BRAIN-TUMOR MODEL; IN-VITRO; CONTROLLED-RELEASE; RAT BRAINS; FORMULATION; IMPLANTS; SN-38; LIVER; BIOCOMPATIBILITY; COPOLYMERS;
D O I：
10.3109/10837450.2016.1163389
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this work, paclitaxel-encapsulated polymeric depots were prepared and characterized as drug delivery system for cancer chemotherapy against hepatocellular carcinoma. Effects of different parameters, including drug-loading content, polymer concentration and depot weight on depot formation, percentage of sustained-release taxol and drug release profile were evaluated. Paclitaxel-loaded depots were successfully formed at the polymer concentration above 25% w/v. For all formulations, paclitaxel could be encapsulated with very high percentage of sustained-release taxol (>90%). The release rate of paclitaxel from depots could be controlled by the amount of drug-loading content, polymer concentration and depot weight. Cytotoxicity against liver cancer cell line, HepG2, was evaluated by medium extraction method. Paclitaxel releasing from depots showed cytotoxic effect against HepG2 at different incubation times, whereas blank depots exhibited no cytotoxicity.
引用
收藏
页码：652 / 658
页数：7
相关论文
共 29 条
[1]   Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles [J].
Ahmed, F ;
Discher, DE .
JOURNAL OF CONTROLLED RELEASE, 2004, 96 (01) :37-53
[2]   The spindle checkpoint, aneuploidy, and cancer [J].
Bharadwaj, R ;
Yu, HT .
ONCOGENE, 2004, 23 (11) :2016-2027
[3]   Biocompatibility study of glycofurol in rat brains [J].
Boongird, Atthaporn ;
Nasongkla, Norased ;
Hongeng, Suradej ;
Sukdawong, Nongyao ;
Sa-Nguanruang, Waridtha ;
Larbcharoensub, Noppadol .
EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 236 (01) :77-83
[4]   BLOCK-COPOLYMERS OF L-LACTIDE AND POLY(ETHYLENE GLYCOL) FOR BIOMEDICAL APPLICATIONS [J].
CERRAI, P ;
TRICOLI, M ;
LELLI, L ;
GUERRA, GD ;
DELGUERRA, RS ;
CASCONE, MG ;
GIUSTI, P .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1994, 5 (6-7) :308-313
[5]   Tri-component copolymer rods as an implantable reservoir drug delivery system for constant and controllable drug release rate [J].
Chanlen, Tararat ;
Hongeng, Suradej ;
Nasongkla, Norased .
JOURNAL OF POLYMER RESEARCH, 2012, 19 (12)
[6]   Biocompatibility of injectable chitosan-phospholipid implant systems [J].
De Souza, Raquel ;
Zahedi, Payam ;
Allen, Christine J. ;
Piquette-Miller, Micheline .
BIOMATERIALS, 2009, 30 (23-24) :3818-3824
[7]   Acquisition of paclitaxel resistance via PI3K-dependent epithelial-mesenchymal transition in A2780 human ovarian cancer cells [J].
Du, Fangfang ;
Wu, Xiaohong ;
Liu, Yanjun ;
Wang, Teng ;
Qi, Xiaowei ;
Mao, Yong ;
Jiang, Li ;
Zhu, Yifei ;
Chen, Yun ;
Zhu, Ruiyu ;
Han, Xiaofeng ;
Jin, Jian ;
Ma, Xin ;
Hua, Dong .
ONCOLOGY REPORTS, 2013, 30 (03) :1113-1118
[8]  
Eliaz RE, 2000, J BIOMED MATER RES, V50, P388, DOI 10.1002/(SICI)1097-4636(20000605)50:3<388::AID-JBM13>3.3.CO
[9]  
2-6
[10]   Robust and prolonged gene expression from injectable polymeric implants [J].
Eliaz, RE ;
Szoka, FC .
GENE THERAPY, 2002, 9 (18) :1230-1237
123