Organizing knowledge to enable personalization of medicine in cancer

被引：60

作者：

Good, Benjamin M. ^{[1
]}

Ainscough, Benjamin J. ^{[2
,3
]}

McMichael, Josh F. ^{[2
]}

Su, Andrew I. ^{[1
]}

Griffith, Obi L. ^{[2
,4
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

[2] Washington Univ, Sch Med, Genome Inst, St Louis, MO 63108 USA

[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

来源：

GENOME BIOLOGY | 2014年 / 15卷 / 08期

关键词：

LUNG-CANCER; GENE WIKI; GENOME; MUTATIONS; COMMUNITY; ONTOLOGY; UNIFICATION; ANNOTATION; TOOL;

D O I：

10.1186/s13059-014-0438-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interpretation of the clinical significance of genomic alterations remains the most severe bottleneck preventing the realization of personalized medicine in cancer. We propose a knowledge commons to facilitate collaborative contributions and open discussion of clinical decision-making based on genomic events in cancer.

引用

页数：9

共 41 条

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Yook, Karen ;

Harris, Todd W. ;

Bieri, Tamberlyn ;

Cabunoc, Abigail ;

Chan, Juancarlos ;

Chen, Wen J. ;

Davis, Paul ;

de la Cruz, Norie ;

Duong, Adrian ;

Fang, Ruihua ;

Ganesan, Uma ;

Grove, Christian ;

Howe, Kevin ;

Kadam, Snehalata ;

Kishore, Ranjana ;

Lee, Raymond ;

Li, Yuling ;

Muller, Hans-Michael ;

Nakamura, Cecilia ;

Nash, Bill ;

Ozersky, Philip ;

Paulini, Michael ;

Raciti, Daniela ;

Rangarajan, Arun ;

Schindelman, Gary ;

Shi, Xiaoqi ;

Schwarz, Erich M. ;

Tuli, Mary Ann ;

Van Auken, Kimberly ;

Wang, Daniel ;

Wang, Xiaodong ;

Williams, Gary ;

Hodgkin, Jonathan ;

Berriman, Matthew ;

Durbin, Richard ;

Kersey, Paul ;

Spieth, John ;

Stein, Lincoln ;

Sternberg, Paul W. .

NUCLEIC ACIDS RESEARCH, 2012, 40 (D1) :D735-D741

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