Organizing knowledge to enable personalization of medicine in cancer

被引：60

作者：

Good, Benjamin M. ^{[1
]}

Ainscough, Benjamin J. ^{[2
,3
]}

McMichael, Josh F. ^{[2
]}

Su, Andrew I. ^{[1
]}

Griffith, Obi L. ^{[2
,4
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

[2] Washington Univ, Sch Med, Genome Inst, St Louis, MO 63108 USA

[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

来源：

GENOME BIOLOGY | 2014年 / 15卷 / 08期

关键词：

LUNG-CANCER; GENE WIKI; GENOME; MUTATIONS; COMMUNITY; ONTOLOGY; UNIFICATION; ANNOTATION; TOOL;

D O I：

10.1186/s13059-014-0438-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interpretation of the clinical significance of genomic alterations remains the most severe bottleneck preventing the realization of personalized medicine in cancer. We propose a knowledge commons to facilitate collaborative contributions and open discussion of clinical decision-making based on genomic events in cancer.

引用

页数：9

共 41 条

[1]

[Anonymous], 2005, Proceedings of the 2005 International ACM SIGGROUP Conference on Supporting Group Work. GROUP'05. Sanibel Island, DOI [DOI 10.1145/1099203.1099205, 10.1145/1099203.1099205]

[2] Gene Ontology: tool for the unification of biology [J].

Ashburner, M ;

Ball, CA ;

Blake, JA ;

Botstein, D ;

Butler, H ;

Cherry, JM ;

Davis, AP ;

Dolinski, K ;

Dwight, SS ;

Eppig, JT ;

Harris, MA ;

Hill, DP ;

Issel-Tarver, L ;

Kasarskis, A ;

Lewis, S ;

Matese, JC ;

Richardson, JE ;

Ringwald, M ;

Rubin, GM ;

Sherlock, G .

NATURE GENETICS, 2000, 25 (01) :25-29

[3] Directly e-mailing authors of newly published papers encourages community curation [J].

Bunt, Stephanie M. ;

Grumbling, Gary B. ;

Field, Helen I. ;

Marygold, Steven J. ;

Brown, Nicholas H. ;

Millburn, Gillian H. .

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2012,

[4]

den Dunnen JT, 2000, HUM MUTAT, V15, P7

[5] Standardized decision support in next generation sequencing reports of somatic cancer variants [J].

Dienstmann, Rodrigo ;

Dong, Fei ;

Borger, Darrell ;

Dias-Santagata, Dora ;

Ellisen, Leif W. ;

Le, Long P. ;

Iafrate, A. John .

MOLECULAR ONCOLOGY, 2014, 8 (05) :859-873

[6] The Sequence Ontology: a tool for the unification of genome annotations [J].

Eilbeck, K ;

Lewis, SE ;

Mungall, CJ ;

Yandell, M ;

Stein, L ;

Durbin, R ;

Ashburner, M .

GENOME BIOLOGY, 2005, 6 (05)

[7] Metcalfe's law and the biology information commons [J].

Friend, Stephen H. ;

Norman, Thea C. .

NATURE BIOTECHNOLOGY, 2013, 31 (04) :297-303

[8] A census of human cancer genes [J].

Futreal, PA ;

Coin, L ;

Marshall, M ;

Down, T ;

Hubbard, T ;

Wooster, R ;

Rahman, N ;

Stratton, MR .

NATURE REVIEWS CANCER, 2004, 4 (03) :177-183

[9] Rfam: Wikipedia, clans and the "decimal" release [J].

Gardner, Paul P. ;

Daub, Jennifer ;

Tate, John ;

Moore, Benjamin L. ;

Osuch, Isabelle H. ;

Griffiths-Jones, Sam ;

Finn, Robert D. ;

Nawrocki, Eric P. ;

Kolbe, Diana L. ;

Eddy, Sean R. ;

Bateman, Alex .

NUCLEIC ACIDS RESEARCH, 2011, 39 :D141-D145

[10] Internet encyclopaedias go head to head [J].

Giles, J .

NATURE, 2005, 438 (7070) :900-901

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