ON-LINE SPE ON RESTRICTED ACCESS ADSORBENT FOR HPLC-MS/MS ANALYSIS OF FELODIPINE IN PLASMA SAMPLES

被引：7

作者：

Albu, Florin ^{[2
]}

Sora, Iuliana ^{[2
]}

Tache, Florentin ^{[1
]}

David, Victor ^{[1
]}

Medvedovici, Andrei ^{[1
,2
]}

机构：

[1] Univ Bucharest, Fac Chem, Dept Analyt Chem, Bucharest 050663, Romania

[2] SC LaborMed Pharma SA, Bioanalyt Lab, Bucharest, Romania

来源：

ANALYTICAL LETTERS | 2010年 / 43卷 / 7-8期

关键词：

APCI; Bioequivalence; Felodipine; HPLC; MS/MS detection; On-line SPE; Plasma samples; Restricted access material; Validation; LIQUID-CHROMATOGRAPHY; SENSITIVE DETERMINATION; MASS-SPECTROMETRY; COLUMN;

D O I：

10.1080/00032710903518740

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Direct plasma loading on a LiChrospher ADS C18 cartridge on-line coupled to an analytical Zorbax XDB C18 column was used to analyze felodipine by means of positive atmospheric pressure chemical ionization (APCI) tandem mass spectrometric (MS/MS) detection. Appropriate sensitivity, accuracy, and precision were obtained using an ion trap mass analyzer operated in a multiple reaction monitoring (MRM) mode. Diethyl-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate) was used as an internal standard. The method was fully validated. The method was successfully applied to a pilot bioequivalence study made on extended release oral dosage forms containing 10 mg of felodipine, under fed and fasting conditions.

引用

页码：1330 / 1343

页数：14

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