Levetiracetam prophylaxis in pediatric migraine - An open-label study

被引：58
作者：
Pakalnis, Ann [1 ]
Kring, Donna [1 ]
Meier, Lisa [1 ]
机构：
[1] Childrens Hosp, Dept Neurol, Columbus, OH 43205 USA
来源：
HEADACHE | 2007年 / 47卷 / 03期
关键词：
migraine; headache; pediatric; levetiracetam;
D O I：
10.1111/j.1526-4610.2007.00728.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background.-Migraine is common in the pediatric population. Levetiracetam, an anti-epileptic drug, has shown some efficacy in small prospective adult headache studies. Methods.-We prospectively evaluated levetiracetam in an open-label study in 20 pediatric migraine patients to assess tolerability and efficacy. Results.-Eighteen of 20 patients had significant reduction in headache frequency. PedMIDAS showed significant decrease in disability scores, side effects were minimal (mild behavioral changes). Conclusion.-Levetiracetam had some efficacy in reducing migraine frequency and disability. Further larger studies are warranted, possibly utilizing a placebo-controlled design.
引用
收藏
页码：427 / 430
页数：4
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