G protein coupled receptor structure and activation

被引：423

作者：

Kobilka, Brian K. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Mol& Cellular Physiol, Stanford, CA 94305 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2007年 / 1768卷 / 04期

关键词：

GPCR; 7TM; structure; conformational change; efficacy;

D O I：

10.1016/j.bbamem.2006.10.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The members of this large family of membrane proteins are activated by a spectrum of structurally diverse ligands, and have been shown to modulate the activity of different signaling pathways in a ligand specific manner. In this manuscript I will review what is known about the structure and mechanism of activation of GPCRs focusing primarily on two model systems, rhodopsin and the beta(2) adrenoceptor. (c) 2006 Elsevier B.V All rights reserved.

引用

页码：794 / 807

页数：14

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