The impact of a 4-hour sleep delay on slow wave activity in twins discordant for chronic fatigue syndrome

被引:28
作者
Armitage, Roseanne
Landis, Carol
Hoffmann, Robert
Lentz, Martha
Watson, Nathaniel F.
Goldberg, Jack
Buchwald, Dedra
机构
[1] Univ Michigan, Sleep & Chronophysiol Lab, Dept Psychiat, Ann Arbor, MI 48105 USA
[2] Univ Washington, Dept Biobehav Nursing & Hlth Syst, Seattle, WA 98195 USA
[3] Univ Washington, Dept Neurol, Seattle, WA 98195 USA
[4] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[5] Univ Washington, Dept Med, Seattle, WA 98195 USA
关键词
chronic fatigue syndrome; sleep; power spectral analysis; homeostasis; slow wave activity; twins;
D O I
10.1093/sleep/30.5.657
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: Chronic fatigue syndrome (CFS) has been associated with altered amounts of slow wave sleep, which could reflect reduced delta electroencephalograph (EEG) activity and impaired sleep regulation. To evaluate this hypothesis, we examined the response to a sleep regulatory challenge in CFS. Design: The first of 3 consecutive nights of study served as laboratory adaptation, Baseline sleep was assessed on the second night. On the third night, bedtime was delayed by 4 hours, followed by recovery sleep. Total available sleep time was held constant on all nights. Setting: A research sleep laboratory. Participants: 13 pairs of monozygotic twins discordant for CFS. Interventions: N/A Measurements and Results: Power spectral analysis quantified slow wave activity (SWA) in the 0.5-3.9 Hz band in successive NREM periods (stage 2, 3, or 4) on each night. To ensure comparability, analyses were restricted to the first 4 NREM periods on each night. Data were coded for NREM period and twin pair. Repeated-measures analysis of variance (ANOVA) contrasted sleep delay effects across NREM periods between twin pairs. A second ANOVA calculated the SWA in each NREM period in recovery sleep relative to baseline SWA. The 2 groups of twins were similar on baseline SWA power. After sleep delay, CFS twins exhibited significantly less SWA power in the first NREM period of recovery sleep and accumulated a smaller percentage of SWA in the first NREM period than their co-twins. Conclusions: CFS is associated with a blunted SWA response to sleep challenge, suggesting that the basic sleep drive and homeostatic response are impaired.
引用
收藏
页码:657 / 662
页数:6
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