Novel fluorescent amphiphilic block copolymers: Controllable morphologies and size by self-assembly

被引：24
|
作者：
Lu, Xiaoju [1 ]
Gong, Shuling [1 ]
Meng, Lingzhi [1 ]
Li, Cheng [1 ]
Liang, Feng [1 ]
Wu, Zhaoqiang [1 ]
Zhang, Lifen [1 ]
机构：
[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
来源：
EUROPEAN POLYMER JOURNAL | 2007年 / 43卷 / 07期
关键词：
amphiphilic copolymer; fluorescent; self-assembly; vesicles;
D O I：
10.1016/j.eurpolymj.2007.04.006
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
New fluorescent amphiphilic copolymers polyacrylamide-b-poly(p-methacrylamido)acetophenone thiosemicarbazone (PAM-b-PMATC) were synthesized by atom transfer radical polymerization (ATRP) method. The structures of polymers were confirmed by H-1 NMR and gel permeation chromatography-multi-angle laser light scatting (GPC-MALLS). PAM-b-PMATC showed a broad emission peak about 388 nm excited at 318 nm in aqueous solution. The self-assembly behavior of PAM-b-PMATC in tile binary mixture formamide/water was observed by transmission electron microscope (TEM). It indicated that PAM-b-PMATC-I and -Il with the same PAM block self-assembled to vesicles and sunflower-like micelles. The water fraction in the mixture could control the size and thickness of vesicles. Vesicle size increased from 50 to 420 nm and vesicle thickness changed from 5 to 50 nm with water content ranging from 33 to 90 vol.%. In addition, the cytotoxicity in vitro of PAM-b-PMATC-I and its nanoparticles loaded with methotrexate (MTX) were evaluated by MTT assay. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2891 / 2900
页数：10
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