Role of innate and adaptive immune mechanisms in cardiac injury and repair

被引：491

作者：

Epelman, Slava ^{[1
]}

Liu, Peter P.

Mann, Douglas L. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Ctr Cardiovasc Res,Div Cardiol, St Louis, MO 63110 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ACUTE MYOCARDIAL-INFARCTION; COXSACKIEVIRUS B3-INDUCED MYOCARDITIS; COLONY-STIMULATING FACTOR-1; GENE-EXPRESSION PROFILES; REGULATORY T-CELLS; BONE-MARROW; INFLAMMATORY MONOCYTES; FIBROBLAST PRECURSORS; NEUTROPHIL DEPLETION; TRANSCRIPTION FACTOR;

D O I：

10.1038/nri3800

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the advances that have been made in developing new therapeutics, cardiovascular disease remains the leading cause of worldwide mortality. Therefore, understanding the mechanisms underlying cardiovascular tissue injury and repair is of prime importance. Following cardiac tissue injury, the immune system has an important and complex role in driving both the acute inflammatory response and the regenerative response. This Review summarizes the role of the immune system in cardiovascular disease - focusing on the idea that the immune system evolved to promote tissue homeostasis following injury and/or infection, and that the inherent cost of this evolutionary development is unwanted inflammatory damage.

引用

页码：117 / 129

页数：13

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