MicroSPECT imaging of triple negative breast cancer cell tumor xenografted in athymic mice with radioiodinated anti-ICAM-1 monoclonal antibody

被引：11
作者：
You, Linyi [1 ,2 ]
Wang, Xiangyu [1 ,2 ]
Guo, Zhide [1 ,2 ]
Zhang, Deliang [1 ,2 ]
Zhang, Pu [1 ,2 ]
Li, Jindian [1 ,2 ]
Su, Xinhui [3 ]
Pan, Weimin [4 ]
Zhang, Xianzhong [1 ,2 ]
机构：
[1] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, XiangAn South Rd, Xiamen 361102, Peoples R China
[2] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, XiangAn South Rd, Xiamen 361102, Peoples R China
[3] Xiamen Univ, Zhongshan Hosp Affiliated, Dept Nucl Med, Hubin South Rd, Xiamen 361004, Peoples R China
[4] Hainan Med Univ, Dept Nucl Med, Affiliated Hosp 1, 31 Longhua Rd, Haikou 570102, Hainan, Peoples R China
来源：
APPLIED RADIATION AND ISOTOPES | 2018年 / 139卷
基金：
中国国家自然科学基金;
关键词：
Radioiodination; SPECT; ICAM-1; Triple negative breast cancer; INTERCELLULAR-ADHESION MOLECULE-1; ICAM-1; EXPRESSION; DISEASE; CLASSIFICATION; HETEROGENEITY; ENLIMOMAB; INVASION; MUC1;
D O I：
10.1016/j.apradiso.2018.04.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Intercellular adhesion molecule-1(ICAM-1) is a potential molecular target and biomarker for triple negative breast cancer (TNBC) therapy and diagnosis. In this study, aICAM-1 was radioiodinated with I-125/I-131 in high radiochemical yield and the probes for TNBC tumor targeting and radioimmunotherapy were evaluated in tumor-bearing mice. High and specific accumulation of I-125-aICAM1 in TNBC MDA-MB-231 tumor was observed in SPECT imaging and the tumor grew was inhibited obviously by I-131-aICAM1. Thus, the radioiodinated aICAM1 could serve as potential agents for TNBC theranostics.
引用
收藏
页码：20 / 25
页数：6
相关论文
共 34 条
  • [1] Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
    Bianchini, Giampaolo
    Balko, Justin M.
    Mayer, Ingrid A.
    Sanders, Melinda E.
    Gianni, Luca
    [J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2016, 13 (11) : 674 - 690
  • [2] Molecular classification and molecular forecasting of breast cancer: Ready for clinical application?
    Brenton, JD
    Carey, LA
    Ahmed, AA
    Caldas, C
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (29) : 7350 - 7360
  • [3] The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    Carey, Lisa A.
    Dees, E. Claire
    Sawyer, Lynda
    Gatti, Lisa
    Moore, Dominic T.
    Collichio, Frances
    Ollila, David W.
    Sartor, Carolyn I.
    Graham, Mark L.
    Perou, Charles M.
    [J]. CLINICAL CANCER RESEARCH, 2007, 13 (08) : 2329 - 2334
  • [4] Breast cancer as a global health concern
    Coughlin, Steven S.
    Ekwueme, Donatus U.
    [J]. CANCER EPIDEMIOLOGY, 2009, 33 (05) : 315 - 318
  • [5] Targeted imaging: an important biomarker for understanding disease progression in the era of personalized medicine
    Eckelman, William C.
    Reba, Richard C.
    Kellof, Gary J.
    [J]. DRUG DISCOVERY TODAY, 2008, 13 (17-18) : 748 - 759
  • [6] The Global Burden of Cancer 2013 Global Burden of Disease Cancer Collaboration
    Fitzmaurice, Christina
    Dicker, Daniel
    Pain, Amanda
    Hamavid, Hannah
    Moradi-Lakeh, Maziar
    Maclntyre, Michael F.
    Allen, Christine
    Hansen, Gillian
    Woodbrook, Rachel
    Wolfe, Charles
    Hamadeh, Randah R.
    Moore, Ami
    Werdecker, Andrea
    Gessner, Bradford D.
    Te Ao, Braden
    McMahon, Brian
    Karimkhani, Chante
    Yu, Chuanhua
    Cooke, Graham S.
    Schwebel, David C.
    Carpenter, David O.
    Pereira, David M.
    Nash, Denis
    Kazi, Dhruv S.
    De Leo, Diego
    Plass, Dietrich
    Ukwaja, Kingsley N.
    Thurston, George D.
    Jin, Kim Yun
    Simard, Edgar P.
    Mills, Edward
    Park, Eun-Kee
    Catala-Lopez, Ferran
    DeVeber, Gabrielle
    Gotay, Carolyn
    Khan, Gulfaraz
    Hosgood, H. Dean, III
    Santos, Itamar S.
    Leasher, Janet L.
    Singh, Jasvinder
    Leigh, James
    Jonas, Jost B.
    Sanabria, Juan
    Beardsley, Justin
    Jacobsen, Kathryn H.
    Takahashi, Ken
    Franklin, Richard C.
    Ronfani, Luca
    Montico, Marcella
    Naldi, Luigi
    [J]. JAMA ONCOLOGY, 2015, 1 (04) : 505 - 527
  • [7] FRAKER PJ, 1978, BIOCHEM BIOPH RES CO, V80, P849, DOI 10.1016/0006-291X(78)91322-0
  • [8] ICAM-1 as a molecular target for triple negative breast cancer
    Guo, Peng
    Huang, Jing
    Wang, Liya
    Jia, Di
    Yang, Jiang
    Dillon, Deborah A.
    Zurakowski, David
    Mao, Hui
    Moses, Marsha A.
    Auguste, Debra T.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (41) : 14710 - 14715
  • [9] Hayes SH, 2009, INT J CLIN EXP PATHO, V2, P553
  • [10] Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex:: molecular and functional study of novel α-methylene-γ-butyrolactone derivatives
    Huang, WC
    Chan, ST
    Yang, TL
    Tzeng, CC
    Chen, CC
    [J]. CARCINOGENESIS, 2004, 25 (10) : 1925 - 1934
1234