Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

被引：104

作者：

Breton, Carrie V. ^{[1
]}

Landon, Remy ^{[1
]}

Kahn, Linda G. ^{[2
]}

Enlow, Michelle Bosquet ^{[3
,4
]}

Peterson, Alicia K. ^{[1
]}

Bastain, Theresa ^{[1
]}

Braun, Joseph ^{[5
]}

Comstock, Sarah S. ^{[6
]}

Duarte, Cristiane S. ^{[7
,8
]}

Hipwell, Alison ^{[9
]}

Ji, Hong ^{[10
]}

LaSalle, Janine M. ^{[11
]}

Miller, Rachel L. ^{[12
]}

Musci, Rashelle ^{[13
]}

Posner, Jonathan ^{[7
,8
]}

Schmidt, Rebecca ^{[14
]}

Suglia, Shakira F. ^{[15
]}

Tung, Irene ^{[9
]}

Weisenberger, Daniel ^{[16
]}

Zhu, Yeyi ^{[17
,18
]}

Fry, Rebecca ^{[19
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA

[2] NYU, Dept Pediat, Grossman Sch Med, New York, NY 10016 USA

[3] Boston Childrens Hosp, Dept Psychiat, Boston, MA USA

[4] Harvard Med Sch, Boston, MA 02115 USA

[5] Brown Univ, Dept Epidemiol, Sch Publ Hlth, Providence, RI 02912 USA

[6] Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA

[7] Columbia Univ, Dept Psychiat, Vagelos Coll Phys & Surg, Irving Med Ctr, New York, NY USA

[8] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[9] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[10] Univ Calif Davis, Sch Vet Med, Dept Anat Physiol & Cell Biol, Calif Natl Primate Res Ctr, Davis, CA 95616 USA

[11] Univ Calif Davis, MIND Inst, Dept Med Microbiol & Immunol, Genome Ctr, Davis, CA 95616 USA

[12] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[13] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA

[14] UC Davis Sch Med, Dept Publ Hlth Sci, Davis, CA USA

[15] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA

[16] Univ Southern Calif, Dept Biochem & Mol Med, Los Angeles, CA 90007 USA

[17] Univ Calif San Francisco, Div Res, Kaiser Permanente Northern Calif, San Francisco, CA USA

[18] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[19] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC USA

来源：

COMMUNICATIONS BIOLOGY | 2021年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SPERM DNA FRAGMENTATION; HIGH-FAT DIET; GRANDMATERNAL SMOKING PATTERNS; PRENATAL EXPOSURE; CIGARETTE-SMOKE; BIRTH-WEIGHT; IN-UTERO; TRANSGENERATIONAL INHERITANCE; MATERNAL SMOKING; GRANDMOTHERS SMOKING;

D O I：

10.1038/s42003-021-02316-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Environmental exposures, psychosocial stressors and nutrition are all potentially important influences that may impact health outcomes directly or via interactions with the genome or epigenome over generations. While there have been clear successes in large-scale human genetic studies in recent decades, there is still a substantial amount of missing heritability to be elucidated for complex childhood disorders. Mounting evidence, primarily in animals, suggests environmental exposures may generate or perpetuate altered health outcomes across one or more generations. One putative mechanism for these environmental health effects is via altered epigenetic regulation. This review highlights the current epidemiologic literature and supporting animal studies that describe intergenerational and transgenerational health effects of environmental exposures. Both maternal and paternal exposures and transmission patterns are considered, with attention paid to the attendant ethical, legal and social implications. Carrie Breton and colleagues review the literature supporting evidence for transgenerational health effects of environmental exposures by epigenetic mechanisms. This Review summarizes current knowledge based on animal and human cohort studies, and discusses the ethical, legal, and social implications of epigenetic research in humans

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