High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NFκB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes

被引：5

作者：

Starcevic, Kristina ^{[1
]}

Roskaric, Petra ^{[1
]}

Speranda, Marcela ^{[2
]}

Didara, Mislav ^{[2
]}

Kurilj, Andrea Gudan ^{[3
]}

Mauric, Maja ^{[4
]}

Masek, Tomislav ^{[5
]}

机构：

[1] Univ Zagreb, Fac Vet Med, Dept Forens & State Vet Med, Zagreb, Croatia

[2] Univ Osijek, Fac Agr, Dept Anim Sci, Osijek, Croatia

[3] Univ Zagreb, Fac Vet Med, Dept Vet Pathol, Zagreb, Croatia

[4] Univ Zagreb, Fac Vet Med, Dept Anim Husb, Zagreb, Croatia

[5] Univ Zagreb, Fac Vet Med, Dept Anim Nutr & Dietet, Zagreb, Croatia

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2019年 / 149卷

关键词：

Diabetes type 2; Fructose; Streptozotocin; Inflammation; Fatty acids; NF-KAPPA-B; FATTY-ACIDS; OXIDATIVE STRESS; SKELETAL-MUSCLE; GENE-EXPRESSION; DRINKING-WATER; LINOLEIC-ACID; EPA/AA RATIO; INSULIN; LIVER;

D O I：

10.1016/j.plefa.2019.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We studied the influence of dietary n6/n3 ratio and docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids supplementation on fatty acid profile, lipid peroxidation and NF kappa/p50 expression in diabetes type 2. Treatments consisted of three dietary n6/n3 ratios: 6 (Control), 50 (high n6) and I (DHA and EPA supplemented). Half of the rats in each of the dietary treatments were made diabetic using the fructose/low-streptozotocin model. The Control and high n6 diets decreased EPA/ARA (arachidonic acid) ratios in the plasma and in the hepatic tissue suggesting proinflammatory fatty acid profile. The high n6 diet additionally increased the 4-HNE and NF kappa/p50 expression in the hepatic tissue. These changes were the consequence of a decrease in the plasma content of DHA and EPA and an increase in the content of arachidonic acid in the liver neutral lipids. The supplementation with the DHA and EPA attenuated the change in EPA/ARA ratios, which imply the importance of the n6/n3 ratio in diabetes type 2.

引用

页码：1 / 7

页数：7

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