Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets

被引：62

作者：

Harish, Vancha ^{[1
]}

Haque, Effi ^{[2
]}

Smiech, Magdalena ^{[2
]}

Taniguchi, Hiroaki ^{[2
]}

Jamieson, Sarah ^{[3
]}

Tewari, Devesh ^{[4
]}

Bishayee, Anupam ^{[3
]}

机构：

[1] Lovely Profess Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Phagwara 144411, Punjab, India

[2] Polish Acad Sci, Inst Genet & Anim Biotechnol, Dept Expt Embryol, PL-05552 Jastrzebiec, Poland

[3] Lake Erie Coll Osteopath Med, Bradenton, FL 34211 USA

[4] Lovely Profess Univ, Sch Pharmaceut Sci, Dept Pharmacognosy, Phagwara 144411, Punjab, India

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 09期

关键词：

xanthohumol; Humulus lupulus L; cancer; proliferation; apoptosis; therapy; prevention; molecular targets; HOPS HUMULUS-LUPULUS; CELL-CYCLE ARREST; B INHIBITOR XANTHOHUMOL; NOTCH SIGNALING PATHWAY; HEPATIC STELLATE CELLS; FACTOR-KAPPA-B; PRENYLATED CHALCONE; CANCER-CELLS; IN-VIVO; APOPTOSIS;

D O I：

10.3390/ijms22094478

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure-activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.

引用

页数：19

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