Luciferase immunoprecipitation systems for measuring antibodies in autoimmune and infectious diseases

被引：68
作者：
Burbelo, Peter D. [1 ,2 ,3 ]
Lebovitz, Evan E. [1 ,2 ,3 ]
Notkins, Abner L. [1 ,2 ,3 ]
机构：
[1] NIDCR, Dent Clin Res Core, NIH, Bethesda, MD 20892 USA
[2] NIH, Ctr Clin, Dept Perioperat Med, Bethesda, MD 20892 USA
[3] NIDCR, Expt Med Sect, Lab Sensory Biol, NIH, Bethesda, MD 20892 USA
来源：
TRANSLATIONAL RESEARCH | 2015年 / 165卷 / 02期
基金：
美国国家卫生研究院;
关键词：
EPSTEIN-BARR-VIRUS; WUCHERERIA-BANCROFTI; 4-ANTIGEN MIXTURE; AUTOANTIBODIES; RESPONSES; ASSAY; ONSET; HUMAN-HERPESVIRUS-8; IDENTIFICATION; DIAGNOSIS;
D O I：
10.1016/j.trsl.2014.08.006
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Antibody profiles have the potential to revolutionize personalized medicine by providing important information related to autoimmunity against self-proteins and exposure to infectious agents. One immunoassay technology, luciferase immunoprecipitation systems (LIPS), harnesses light-emitting recombinant proteins to generate robust, high-quality antibody data often spanning a large dynamic range of detection. Here, we describe the general format of LIPS and discuss studies using the technology to measure autoantibodies in several human autoimmune diseases including type 1 diabetes, Sjogren's syndrome, systemic lupus erythematosus, and immunodeficiencies secondary to anticytokine autoantibodies. We also describe the usefulness of evaluating antibodies against single or multiple antigens from infectious agents for diagnosis, pathogen discovery, and for obtaining individual exposure profiles. These diverse findings support the notion that the LIPS is a useful technology for generating antibody profiles for personalized diagnosis and monitoring of human health.
引用
收藏
页码：325 / 335
页数：11
相关论文
共 63 条
[1]  
Alagaili AN, 2014, MBIO, V5, DOI [10.1128/mBio.00884-14, 10.1128/mBio.01482-14]
[2]   Development of autoantibodies before the clinical onset of systemic lupus erythematosus [J].
Arbuckle, MR ;
McClain, MT ;
Rubertone, MV ;
Scofield, RH ;
Dennis, GJ ;
James, JA ;
Harley, JB .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (16) :1526-1533
[3]   Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection [J].
Bisoffi, Zeno ;
Buonfrate, Dora ;
Sequi, Marco ;
Mejia, Rojelio ;
Cimino, Ruben O. ;
Krolewiecki, Alejandro J. ;
Albonico, Marco ;
Gobbo, Maria ;
Bonafini, Stefania ;
Angheben, Andrea ;
Requena-Mendez, Ana ;
Munoz, Jose ;
Nutman, Thomas B. .
PLOS NEGLECTED TROPICAL DISEASES, 2014, 8 (01) :38
[4]   Adult-Onset Immunodeficiency in Thailand and Taiwan [J].
Browne, Sarah K. ;
Burbelo, Peter D. ;
Chetchotisakd, Ploenchan ;
Suputtamongkol, Yupin ;
Kiertiburanakul, Sasisopin ;
Shaw, Pamela A. ;
Kirk, Jennifer L. ;
Jutivorakool, Kamonwan ;
Zaman, Rifat ;
Ding, Li ;
Hsu, Amy P. ;
Patel, Smita Y. ;
Olivier, Kenneth N. ;
Lulitanond, Viraphong ;
Mootsikapun, Piroon ;
Anunnatsiri, Siriluck ;
Angkasekwinai, Nasikarn ;
Sathapatayavongs, Boonmee ;
Hsueh, Po-Ren ;
Shieh, Chi-Chang ;
Brown, Margaret R. ;
Thongnoppakhun, Wanna ;
Claypool, Reginald ;
Sampaio, Elizabeth P. ;
Thepthai, Charin ;
Waywa, Duangdao ;
Dacombe, Camilla ;
Reizes, Yona ;
Zelazny, Adrian M. ;
Saleeb, Paul ;
Rosen, Lindsey B. ;
Mo, Allen ;
Iadarola, Michael ;
Holland, Steven M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (08) :725-734
[5]   A simplified immunoprecipitation method for quantitatively measuring antibody responses in clinical sera samples by using mammalian-produced Renilla luciferase-antigen fusion proteins -: art. no. 22 [J].
Burbelo, PD ;
Goldman, R ;
Mattson, TL .
BMC BIOTECHNOLOGY, 2005, 5 (1)
[6]   A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2 [J].
Burbelo, Peter D. ;
Hirai, Hiroki ;
Leahy, Hannah ;
Lernmark, Ake ;
Ivarsson, Sten A. ;
Iadarola, Michael J. ;
Notkins, Abner Louis .
DIABETES CARE, 2008, 31 (09) :1824-1826
[7]   Rapid, novel, specific, high-throughput assay for diagnosis of Loa loa infection [J].
Burbelo, Peter D. ;
Ramanathan, Roshan ;
Klion, Amy D. ;
Iadarola, Michael J. ;
Nutman, Thomas B. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (07) :2298-2304
[8]   High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome [J].
Burbelo, Peter D. ;
Groot, Sandra ;
Dalakas, Marinos C. ;
Iadarola, Michael J. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 366 (01) :1-7
[9]   Rapid antibody quantification and generation of whole proteome antibody response profiles using LIPS (luciferase immunoprecipitation systems) [J].
Burbelo, Peter D. ;
Ching, Kathryn H. ;
Mattson, Thomas L. ;
Light, Jason S. ;
Bishop, Lisa R. ;
Kovacs, Joseph A. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 352 (04) :889-895
[10]   HIV Antibody Characterization as a Method to Quantify Reservoir Size During Curative Interventions [J].
Burbelo, Peter D. ;
Bayat, Ahmad ;
Rhodes, Craig S. ;
Hoh, Rebecca ;
Martin, Jeffrey N. ;
Fromentin, Remi ;
Chomont, Nicolas ;
Huetter, Gero ;
Kovacs, Joseph A. ;
Deeks, Steven G. .
JOURNAL OF INFECTIOUS DISEASES, 2014, 209 (10) :1613-1617
1234567