Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

被引：117

作者：

Breinlinger, Steffen ^{[1
]}

Phillips, Tabitha J. ^{[2
]}

Haram, Brigette N. ^{[2
]}

Mares, Jan ^{[3
,4
,5
]}

Yerena, Jose A. Martinez ^{[3
,5
]}

Hrouzek, Pavel ^{[4
,5
]}

Sobotka, Roman ^{[4
,5
]}

Henderson, W. Matthew ^{[6
]}

Schmieder, Peter ^{[7
]}

Williams, Susan M. ^{[8
]}

Lauderdale, James D. ^{[9
]}

Wilde, H. Dayton ^{[10
]}

Gerrin, Wesley ^{[2
]}

Kust, Andreja ^{[3
]}

Washington, John W. ^{[6
]}

Wagner, Christoph ^{[11
]}

Geier, Benedikt ^{[12
]}

Liebeke, Manuel ^{[12
]}

Enke, Heike ^{[13
]}

Niedermeyer, Timo H. J. ^{[1
]}

Wilde, Susan B. ^{[2
]}

机构：

[1] Martin Luther Univ Halle Wittenberg, Inst Pharm, Halle, Saale, Germany

[2] Univ Georgia, Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA

[3] Czech Acad Sci, Inst Hydrobiol, Biol Ctr, Ceske Budejovice, Czech Republic

[4] Czech Acad Sci, Ctr Algatech, Inst Microbiol, Trebon, Czech Republic

[5] Univ South Bohemia, Fac Sci, Ceske Budejovice, Czech Republic

[6] US EPA, Off Res & Dev, Ctr Environm Measurement & Modeling, Athens, GA USA

[7] Leibniz Forsch Inst Mol Pharmakol FMP, Berlin, Germany

[8] Univ Georgia, Coll Vet Med, Poultry Diagnost & Res Ctr, Dept Populat Hlth, Athens, GA USA

[9] Univ Georgia, Dept Cellular Biol, Athens, GA USA

[10] Univ Georgia, Dept Hort, Athens, GA 30602 USA

[11] Martin Luther Univ Halle Wittenberg, Inst Chem, Halle, Saale, Germany

[12] Max Planck Inst Marine Microbiol MPIMM, Bremen, Germany

[13] Cyano Biotech GmbH, Berlin, Germany

来源：

SCIENCE | 2021年 / 371卷 / 6536期

基金：

美国食品与农业研究所;

关键词：

HYDRILLA-VERTICILLATA; CHEMICAL-CONSTITUENTS; COUPLING-CONSTANTS; ORGANIC-COMPOUNDS; AQUATIC PLANTS; SEDIMENT; NORTH; ASSIGNMENTS; RESERVOIRS; DIVERSITY;

D O I：

10.1126/science.aax9050

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata. Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. hydrillicola. We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production.

引用

页码：1335 / +

页数：90

共 92 条

[11] Establishing a food-chain link between aquatic plant material and avian vacuolar myelinopathy in mallards (Anas platyrhynchos) [J].