Synthesis of 6-Alkynyl-6-hydroxyindoloquinazolinone Scaffolds via Copper-Catalyzed Alkynylation of Tryptanthrins

被引：3

作者：

Guo, Yu ^{[1
]}

Ahmed, Ebrahim-Alkhalil M. A. ^{[1
]}

Liu, Hongxin ^{[1
]}

Li, Xinhua ^{[1
]}

Li, Juan ^{[1
]}

Ma, De-Kun ^{[2
]}

Xiao, Hong-Ping ^{[1
]}

Jiang, Jun ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Zhejiang, Peoples R China

[2] Shaoxing Univ, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Zhejiang, Peoples R China

来源：

SYNLETT | 2021年 / 32卷 / 14期

基金：

中国国家自然科学基金;

关键词：

alkynylation; tryptanthrin; indoloquinazolinone; copper catalysis; PROPARGYLIC ALCOHOLS; EFFICIENT CATALYST; TERMINAL ALKYNES; ALDOL REACTION; KETONES; ALDEHYDES; STRAIGHTFORWARD; DERIVATIVES; HYBRID;

D O I：

10.1055/a-1533-1080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a copper-catalyzed direct alkynylation reaction of tryptanthrins with terminal alkynes under mild reaction conditions. The developed method provides an array of synthetic building blocks of 6-alkynyl-6-hydroxyindoloquinazolinone compounds in moderate to good yields with varied functional group compatibility. Furthermore, the obtained adducts can be smoothly converted into versatile building blocks via hydrogenation, hydration, and further Sonogashira coupling transformations.

引用

页码：1428 / 1432

页数：5

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