Efficient alternative for the reduction of N-trichloroacetyl groups in synthetic chondroitin oligosaccharide intermediates

被引：19

作者：

Vibert, Aude

Lopin-Bon, Chrystel

Jacquinet, Jean-Claude ^{[1
]}

机构：

[1] Univ Orleans, Inst Chim Organ & Analyt, UMR 6005, F-45067 Orleans 2, France

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 14期

关键词：

Zn-Cu reduction; Oligosaccharides; N-Trichloroacetyl group; Chondroitin sulfate; SIZE-DEFINED OLIGOMERS; 2-DEOXY-2-TRICHLOROACETAMIDO-D-GLUCOPYRANOSE DERIVATIVES; STEREOCONTROLLED CONSTRUCTION; REPEATING REGION; HYALURONIC-ACID; STRATEGY; SULFATE; POLYMER; GLYCOPEPTIDE; ELONGATION;

D O I：

10.1016/j.tetlet.2010.02.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient alternative for the reduction of N-trichloroacetyl groups in chondroitin oligosaccharides is reported. It involves the use of Zn-Cu couple in acetic acid, and Was Successfully applied to a large panel of synthetic intermediates useful for the preparation of chondroitin oligomers, a class of natural products with numerous relevant biological functions. (C) 2010 Elsevier Ltd. All rights reserved.

引用

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页码：1867 / 1869

页数：3

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