The co-crystal of two GRAS substances: (citric acid)•(nicotinamide). Formation of four hydrogen bonding heterosynthons in one co-crystal

被引：33
作者：
Lemmerer, Andreas [1 ]
Bernstein, Joel [1 ]
机构：
[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel
来源：
CRYSTENGCOMM | 2010年 / 12卷 / 07期
基金：
美国国家科学基金会; 新加坡国家研究基金会;
关键词：
ACTIVE PHARMACEUTICAL INGREDIENTS; CARBAMAZEPINE-NICOTINAMIDE COCRYSTALS; MOLECULAR-COMPLEXES; CARBOXYLIC-ACIDS; ORGANIC-ACIDS; CITRIC-ACID; PHASES; CRYSTALLIZATION; CAFFEINE; KINETICS;
D O I：
10.1039/b927422g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The co-crystal between the GRAS molecules citric acid and nicotinamide contains four different heteromeric interactions, whose known frequency in other nicotinamide co-crystals further illustrates their robustness.
引用
收藏
页码：2029 / 2033
页数：5
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