Voltage-dependent anion channels: the wizard of the mitochondrial outer membrane

被引：35

作者：

Mertins, Barbara ^{[1
,2
]}

Psakis, Georgios ^{[3
]}

Essen, Lars-Oliver ^{[1
,2
]}

机构：

[1] Univ Marburg, Dept Chem, D-35032 Marburg, Germany

[2] Univ Marburg, Dept Biol, D-35032 Marburg, Germany

[3] Univ Huddersfield, Huddersfield HD1 3DH, W Yorkshire, England

来源：

BIOLOGICAL CHEMISTRY | 2014年 / 395卷 / 12期

关键词：

beta-barrel topology; eukaryotic porin structure; intrinsic apoptotic pathway; ion-channel gating; membrane protein phylogeny; structural plasticity; MOLECULAR-DYNAMICS; VDAC; PROTEIN; MODULATION; LIPIDS; INSIGHTS;

D O I：

10.1515/hsz-2014-0203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs' structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.

引用

页码：1435 / 1442

页数：8

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