Identification of a Novel Second-Generation Circulating Recombinant Form (CRF48_01B) in Malaysia: A Descendant of the Previously Identified CRF33_01B

被引：31

作者：

Li, Yue ^{[1
,2
]}

Tee, Kok Keng ^{[1
,3
,6
]}

Liao, Huanan ^{[1
]}

Hase, Saiki ^{[1
]}

Uenishi, Rie ^{[1
]}

Li, Xiao-Jie ^{[1
,4
]}

Tsuchiura, Takayo ^{[1
]}

Yang, Rongge ^{[2
]}

Govindasamy, Sumathi ^{[3
]}

Yong, Yean Kong ^{[3
]}

Tan, Hong Yien ^{[3
]}

Pybus, Oliver G. ^{[5
]}

Kamarulzaman, Adeeba ^{[3
]}

Takebe, Yutaka ^{[1
,2
]}

机构：

[1] Natl Inst Infect Dis, AIDS Res Ctr, Lab Mol Virol & Epidemiol, Shinjuku Ku, Tokyo 1628640, Japan

[2] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China

[3] Univ Malaya, Ctr Excellence Res AIDS, Kuala Lumpur, Malaysia

[4] Shanghai Jiao Tong Univ, Peoples Hosp 1, Dept Dermatol, Shanghai 200030, Peoples R China

[5] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

[6] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2010年 / 54卷 / 02期

关键词：

Asia; Bayesian coalescent analysis; circulating recombinant form; CRF33_01B; CRF48_01B; injection drug user; Malaysia; phylogeny; time of the most recent common ancestor; IMMUNODEFICIENCY-VIRUS TYPE-1; INJECTING DRUG-USERS; FULL-LENGTH SEQUENCE; KUALA-LUMPUR; CRF01-AE/B RECOMBINANT; RISK POPULATIONS; HIV-1; DYNAMICS; COMPLEX; SUBSTITUTIONS;

D O I：

10.1097/QAI.0b013e3181d82ce5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A molecular epidemiological investigation conducted among injecting drug users in eastern Peninsular Malaysia in 2007 identified a cluster of sequences (n = 3) located outside any known HIV-1 genotype. Analyses of near full-length nucleotide sequences of these strains from individuals with no recognizable linkage revealed that they have an identical subtype structure comprised of CRF01_AE and subtype B', distinct from any known circulating recombinant forms (CRFs). This novel CRF, designated CRF48_01B, is closely related to CRF33_01B, previously identified in Kuala Lumpur. Phylogenetic analysis of multiple CRF48_01B genome regions showed that CRF48_01B forms a monophyletic cluster within CRF33_01B, suggesting that this new recombinant is very likely a descendant of CRF33_01B. CRF48_01B thus represents one of the first examples of a "second-generation'' CRF, generated by additional crossover with pre-existing CRFs. Corroborating these results, Bayesian molecular clock analyses indicated that CRF48_01B emerged in similar to 2001, approximately similar to 8 years after the emergence of CRF33_01B.

引用

页码：129 / 136

页数：8

共 41 条

[1] Recombination confounds the early evolutionary history of human immunodeficiency virus type 1: Subtype G is a circulating recombinant form [J].