Caryophyllene sesquiterpenoids from the endophytic fungus, Pestalotiopsis sp.

被引：29
|
作者：
Liu, Yi [1 ]
Yang, Ming-Hua [1 ]
Wang, Xiao-Bing [1 ]
Li, Tian-Xiao [1 ]
Kong, Ling-Yi [1 ]
机构：
[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
来源：
FITOTERAPIA | 2016年 / 109卷
基金：
中国国家自然科学基金;
关键词：
Caryophyllene sesquiterpenoids; Pestalotiopsis sp; NO inhibition; SAMARIUM(II)-MEDIATED 4-EXO-TRIG CYCLIZATION; FUNGICOLOUS ISOLATE; METABOLITES; ALCOHOLS;
D O I：
10.1016/j.fitote.2015.12.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Eight new caryophyllene sesquiterpenoids named pestaloporinates A-G (1-7) and 14-acetylhumulane (8) have been isolated from the solid cultures of an endophytic fungus Pestalotiopsis sp., which was obtained from the fresh stem bark of Melia azedarach Linn. Their structures as well as absolute configurations were determined by spectroscopic data, ECD experimentation, and single-crystal X-ray diffraction. Among all the isolates, compound 2 displayed potent inhibitory activity with IC50 value of 19.0 mu M during the evaluation of nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：119 / 124
页数：6
相关论文
共 50 条
  • [41] Spirobisnaphthalene Analogues from the Endophytic Fungus Preussia sp.
    Chen, Xiaomei
    Shi, Qiyuan
    Lin, Geng
    Guo, Shunxing
    Yang, Junshan
    JOURNAL OF NATURAL PRODUCTS, 2009, 72 (09): : 1712 - 1715
  • [42] Antimalarial benzoquinones from an endophytic fungus, Xylaria sp.
    Tansuwan, Srinuan
    Pornpakakul, Surachai
    Roengsumran, Sophon
    Petsom, Amorn
    Muangsin, Nongnuj
    Sihanonta, Prakitsin
    Chaichit, Narongsak
    JOURNAL OF NATURAL PRODUCTS, 2007, 70 (10): : 1620 - 1623
  • [43] Metabolites from mangrove endophytic fungus Dothiorella sp.
    Xu, QY
    Wang, JF
    Huang, YJ
    Zheng, ZH
    Song, SY
    Zhang, YM
    Su, WJ
    ACTA OCEANOLOGICA SINICA, 2004, 23 (03) : 541 - 547
  • [44] Hormonemate Derivatives from Dothiora sp., an Endophytic Fungus
    Perez-Bonilla, Mercedes
    Gonzalez-Menendez, Victor
    Perez-Victoria, Ignacio
    de Pedro, Nuria
    Martin, Jesus
    Molero-Mesa, Joaquin
    Casares-Porcel, Manuel
    Gonzalez-Tejero, Maria Reyes
    Vicente, Francisca
    Genilloud, Olga
    Tormo, Jose R.
    Reyes, Fernando
    JOURNAL OF NATURAL PRODUCTS, 2017, 80 (04): : 845 - 853
  • [45] New Metabolites from the Endophytic Fungus Mollisia sp.
    Fan, Nai Wen
    Chang, Hsun Shuo
    Cheng, Ming Jen
    Chan, Hing Yuen
    Hsieh, Sung Yuan
    Liu, Ta Wei
    Chen, Sheng Wen
    Yuan, Gwo Fang
    Chen, Ih Sheng
    CHEMISTRY OF NATURAL COMPOUNDS, 2016, 52 (04) : 585 - 590
  • [46] Metabolites from mangrove endophytic fungus Dothiorella sp.
    XU Qingyan
    Acta Oceanologica Sinica, 2004, (03) : 541 - 547
  • [47] Secondary Metabolites from an Endophytic Fungus Nigrospora sp.
    Huang, Rong
    Wang, Tang
    Xie, Xiao-Song
    Ma, Kai-Xia
    Fang, Xiao-Wei
    Wu, Shao-Hua
    CHEMISTRY OF NATURAL COMPOUNDS, 2016, 52 (04) : 697 - 699
  • [48] A new sesquiterpene from endophytic fungus Aspergillus sp.
    Luo, Shao-Liu
    Li, Guo-Hong
    Liu, Fang-Fang
    Lei, Li-Ping
    Xia, Zhen-Yuan
    Zhang, Ke-Qin
    NATURAL PRODUCT RESEARCH, 2012, 26 (14) : 1334 - 1338
  • [49] Secondary Metabolites from an Endophytic Fungus Nigrospora sp.
    Rong Huang
    Tang Wang
    Xiao-Song Xie
    Kai-Xia Ma
    Xiao-Wei Fang
    Shao-Hua Wu
    Chemistry of Natural Compounds, 2016, 52 : 697 - 699
  • [50] Bioactive spirobisnaphthalenes from the endophytic fungus Berkleasmium sp.
    Zhou, Ligang
    Shan, Tijiang
    Tian, Jin
    Wang, Xiaohan
    Mou, Yan
    Mao, Ziling
    Lai, Daowan
    Wang, Mingan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
12345