Caryophyllene sesquiterpenoids from the endophytic fungus, Pestalotiopsis sp.

被引：29
|
作者：
Liu, Yi [1 ]
Yang, Ming-Hua [1 ]
Wang, Xiao-Bing [1 ]
Li, Tian-Xiao [1 ]
Kong, Ling-Yi [1 ]
机构：
[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
来源：
FITOTERAPIA | 2016年 / 109卷
基金：
中国国家自然科学基金;
关键词：
Caryophyllene sesquiterpenoids; Pestalotiopsis sp; NO inhibition; SAMARIUM(II)-MEDIATED 4-EXO-TRIG CYCLIZATION; FUNGICOLOUS ISOLATE; METABOLITES; ALCOHOLS;
D O I：
10.1016/j.fitote.2015.12.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Eight new caryophyllene sesquiterpenoids named pestaloporinates A-G (1-7) and 14-acetylhumulane (8) have been isolated from the solid cultures of an endophytic fungus Pestalotiopsis sp., which was obtained from the fresh stem bark of Melia azedarach Linn. Their structures as well as absolute configurations were determined by spectroscopic data, ECD experimentation, and single-crystal X-ray diffraction. Among all the isolates, compound 2 displayed potent inhibitory activity with IC50 value of 19.0 mu M during the evaluation of nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：119 / 124
页数：6
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