Prenatal cocaine exposure produces gender-specific motor effects in aged rats

被引:24
|
作者
Markowski, VP
Cox, C
Weiss, B
机构
[1] Univ Rochester, Med Ctr, Dept Environm Med, Sch Med & Dent, Rochester, NY 14642 USA
[2] Univ Rochester, Med Ctr, Dept Biostat, Sch Med & Dent, Rochester, NY 14642 USA
关键词
prenatal cocaine exposure; motor; aging; gender; fixed-ratio; operant behavior;
D O I
10.1016/S0892-0362(97)00076-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This investigation employed a longitudinal analysis of a complex motor skill in rats that were exposed prenatally to cocaine. Offspring were derived from four maternal treatment groups: 50 mg/kg cocaine, their pair-fed controls, 25 mg/kg cocaine, and freely fed controls. Cocaine was administered via gavage from gestation day 6-20. A maternal fostering procedure was used. Pairs of male and female littermates began training when 9, 13, or 19 months old. The behavioral procedure involved fixed-ratio (FR) lever pressing to obtain brief periods of wheel running. The oldest males from the 50 mg/kg, 25 mg/kg, and pair-fed groups performed significantly fewer wheel revolutions per opportunity than females or freely fed males. In general, animals earned fewer opportunities to run as the FR requirement was increased over sessions. However, within each age-by-gender group, subjects from the four treatment groups performed equivalent amounts of lever pressing. The specific effect on the motor aspect of the procedure may have resulted from a reduction of motor coordination, balance, or strength, or a diminished capacity of wheel running to serve as a reinforcing stimulus in a cocaine-sensitive subgroup. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:43 / 53
页数:11
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