Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome

被引：75

作者：

Devaraj, Sridevi ^{[1
,2
]}

Valleggi, Simona ^{[1
,2
]}

Siegel, David ^{[2
]}

Jialal, Ishwarlal ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA

[2] Vet Affairs Med Ctr, Mather, CA USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2010年 / 12卷 / 02期

关键词：

CRP; Metabolic syndrome; Inflammation; Cardiovascular risk; CORONARY-HEART-DISEASE; ACTIVATOR INHIBITOR-1 EXPRESSION; INSULIN-RESISTANCE SYNDROME; AORTIC ENDOTHELIAL-CELLS; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; BRACHIAL-ARTERY; KINASE PATHWAY; OXIDIZED LDL;

D O I：

10.1007/s11883-010-0098-3

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.

引用

页码：110 / 118

页数：9

共 90 条

[1] Measurement of endothelial function and its clinical utility for cardiovascular risk [J].

Al-Qaisi, Mo ;

Kharbanda, Rajesh K. ;

Mittal, Tarun K. ;

Donald, Ann E. .

VASCULAR HEALTH AND RISK MANAGEMENT, 2008, 4 (03) :647-652

[2] NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older [J].

Alexander, CM ;

Landsman, PB ;

Teutsch, SM ;

Haffner, SM .

DIABETES, 2003, 52 (05) :1210-1214

[3] Cardiovascular risk assessment in metabolic syndrome: view from PROCAM [J].

Assmann, G ;

Nofer, JR ;

Schulte, H .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2004, 33 (02) :377-+

[4] Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity [J].

Bakker, Wineke ;

Eringa, Etto C. ;

Sipkema, Pieter ;

van Hinsbergh, Victor W. M. .

CELL AND TISSUE RESEARCH, 2009, 335 (01) :165-189

[5] Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study [J].

Ballantyne, CM ;

Hoogeveen, RC ;

Bang, H ;

Coresh, P ;

Folsom, AR ;

Chambless, LE ;

Myerson, M ;

Wu, KK ;

Sharrett, AR ;

Boerwinkle, E .

ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (21) :2479-2484

[6] Mechanisms of disease - Nuclear factor-kappa b - A pivotal transcription factor in chronic inflammatory diseases [J].

Barnes, PJ ;

Larin, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (15) :1066-1071

[7] C-Reactive Protein Elicits White Blood Cell Activation in Humans [J].

Bisoendial, Radjesh J. ;

Birjmohun, Rakesh S. ;

Akdim, Fatima ;

van't Veer, Cornelis ;

Spek, C. Arnold ;

Hartman, Daniel ;

de Groot, Els R. ;

Bankaitis-Davis, Danute M. ;

Kastelein, John J. P. ;

Stroes, Erik S. G. .

AMERICAN JOURNAL OF MEDICINE, 2009, 122 (06) :582.e1-582.e9

[8] Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults [J].

Brook, RD ;

Bard, RL ;

Rubenfire, M ;

Ridker, PM ;

Rajagopalan, S .

AMERICAN JOURNAL OF CARDIOLOGY, 2001, 88 (11) :1264-1269

[9] Endothelial dysfunction in obesity and insulin resistance: A road to diabetes and heart disease [J].

Caballero, AE .

OBESITY RESEARCH, 2003, 11 (11) :1278-1289

[10] C-REACTIVE PROTEIN INDUCES HUMAN PERIPHERAL-BLOOD MONOCYTES TO SYNTHESIZE TISSUE FACTOR [J].

CERMAK, J ;

KEY, NS ;

BACH, RR ;

BALLA, J ;

JACOB, HS ;

VERCELLOTTI, GM .

BLOOD, 1993, 82 (02) :513-520

← 1 2 3 4 5 6 7 8 9 →