Functionalization of β-cyclodextrin into ambient plasma modified carbon nanotube-thermally reduced graphite oxide for electrochemical sensing of uric acid

Surface of thermally reduced graphite oxide-carbon nanotube (TRGO-CNT) composite is effectively modified by using ambient plasma and functionalized with beta-cyclodextrin (beta CD) for electrochemical detection of uric acid. The plasma modified composite has larger surface area and surface functionalization, more amount of beta CD, and lower impedance compared to the composite without the plasma treatment, resulting in the sensitivity of 0.024 mu A/mu M and limit of detection value of 0.06 mu M in the detection of uric acid which was measured from 10 mu M to 300 mu M. In addition, the composite shows excellent selectivity in the detection of uric acid in presence of ascorbic acid and dopamine simultaneously, proving that the beta CD-TRGO-CNT composite modified by the ambient plasma is a comparable biosensor electrode for the detection of biomolecules. Furthermore, it also exhibited high reproducibility as well as long term stability in the detection of uric acid.