Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

被引：213

作者：

Attanasio, John ^{[1
,2
]}

Wherry, E. John ^{[1
,2
]}

机构：

[1] Univ Penn, Inst Immunol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

IMMUNITY | 2016年 / 44卷 / 05期

基金：

美国国家卫生研究院;

关键词：

T-CELL RESPONSES; HERPESVIRUS ENTRY MEDIATOR; LYMPHOCYTE-ACTIVATION; INHIBITORY RECEPTOR; PD-1; EXPRESSION; PROGRAMMED DEATH-1; VIRUS-INFECTION; CUTTING EDGE; THERAPEUTIC BLOCKADE; NEGATIVE REGULATION;

D O I：

10.1016/j.immuni.2016.04.022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Costimulatory and inhibitory receptors play a key role in regulating immune responses to infections. Recent translation of knowledge about inhibitory receptors such as CTLA-4 and PD-1 into the cancer clinic highlights the opportunities to manipulate these pathways to treat human disease. Studies in infectious disease have provided key insights into the specific roles of these pathways and the effects of their manipulation. Here, recent studies are discussed that have addressed how major inhibitory and costimulatory pathways play a role in regulating immune responses during acute and chronic infections. Mechanistic insights from studies of infectious disease provide opportunities to further expand our toolkit to treat cancer and chronic infections in the clinic.

引用

页码：1052 / 1068

页数：17

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