Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8

被引：19
作者：
Garbati, Michael R. [1 ]
Alco, Goekcen [1 ]
Gilmore, Thomas D. [1 ]
机构：
[1] Boston Univ, Dept Biol, Boston, MA 02215 USA
来源：
CANCER LETTERS | 2010年 / 291卷 / 02期
关键词：
c-Rel; p300; CBP; RC-K8; Diffuse large B-cell lymphoma; NF-KAPPA-B; CREB-BINDING PROTEIN; TRANSACTIVATION DOMAIN; GENE-EXPRESSION; DISTINCT ROLES; MICE LACKING; PHOSPHORYLATION; ACTIVATION; PROLIFERATION; MUTATIONS;
D O I：
10.1016/j.canlet.2009.10.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Human c-Rel (REL) is a member of the NF-kappa B family of transcription factors. REL's normal physiological role is in the regulation of B-cell proliferation and survival. The REL gene is amplified in many human B-cell lymphomas and overexpression of REL can transform chicken lymphoid cells. In this report, histone acetyltransferase p300 enhanced REL-induced transactivation and interacted with REL both in vitro and in REL-transformed chicken spleen cells and the B-lymphoma cell line RC-K8, in which REL is constitutively active and required for proliferation. However, due to a deletion in the EP300 locus, only a C-terminally truncated form of p300 is expressed in RC-K8 cells. These results suggest a role for p300 in REL-mediated oncogenic activity in B lymphoma. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：237 / 245
页数：9
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