Environmental enrichment as a method to improve cognitive function. What can we learn from animal models?

被引：63
作者：
Fischer, Andre [1 ,2 ]
机构：
[1] German Ctr Neurodegenerat Dis DZNE Gottingen, Res Grp Epigenet Neurodegenerat Dis, Grisebachstr 5, D-37077 Gottingen, Germany
[2] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Grisebachstr 5, D-37077 Gottingen, Germany
来源：
NEUROIMAGE | 2016年 / 131卷
关键词：
Environmental enrichment; Epigenetics; Histone-acetylation; Memory; Neurodegeneration; Alzheimer's disease; TRANSGENIC MOUSE MODEL; HUNTINGTONS-DISEASE; HIPPOCAMPAL PLASTICITY; ALZHEIMERS-DISEASE; OCCIPITAL CORTEX; SPATIAL MEMORY; MOTOR DEFICITS; EXERCISE; NEUROGENESIS; STIMULATION;
D O I：
10.1016/j.neuroimage.2015.11.039
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
There is substantial evidence that physical and cognitive exercise can enhance memory function in rodents as well as in humans. In addition various behaviors associated with physical activity have been associated with an increased cognitive reserve and a lower risk to develop age-associated memory decline and age-associated neurodegenerative diseases such as Alzheimer's disease. To better understand the molecular mechanisms that increase brain plasticity in response to exercise will therefore help to develop effective therapeutic strategies to treat memory decline. Here we review the currently available data with a specific focus on neurodegenerative diseases. (C) 2015 Published by Elsevier Inc.
引用
收藏
页码：42 / 47
页数：6
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