Organization of immunological memory by bone marrow stroma

被引：181
作者：
Tokoyoda, Koji [1 ,2 ]
Hauser, Anja E. [1 ]
Nakayama, Toshinori [2 ]
Radbruch, Andreas [1 ]
机构：
[1] Leibniz Inst, German Rheumatism Res Ctr DRFZ, D-10117 Berlin, Germany
[2] Chiba Univ, Grad Sch Med, Dept Immunol, Chiba 2608670, Japan
来源：
NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 03期
关键词：
MESENCHYMAL STEM-CELLS; FOLLICULAR DENDRITIC CELLS; LIVED PLASMA-CELLS; THERAPY POSITION STATEMENT; ACTIVATED T-CELLS; B-CELLS; LYMPH-NODE; RETICULAR CELLS; HOMEOSTATIC PROLIFERATION; ADHESION MOLECULE-1;
D O I：
10.1038/nri2727
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunological memory is a hallmark of the adaptive immune system. Plasma cells and memory B and T cells collectively provide protective immunity and effective secondary immune responses to invading pathogens. Here, we discuss how mesenchymal stromal cells regulate immunological memory by organizing defined numbers of dedicated survival niches for plasma cells and memory T cells in the bone marrow and also, to a lesser extent, in secondary lymphoid organs. An understanding of the biology of mesenchymal stromal cells and their interaction with cells of the immune system is key to fully understanding immunological memory.
引用
收藏
页码：193 / 200
页数：8
相关论文
共 118 条
  • [51] KEATING A, 1982, NATURE, V298, P280, DOI 10.1038/298280a0
  • [52] CULTURED MARROW STROMAL CELLS EXPRESS COMMON ACUTE LYMPHOBLASTIC-LEUKEMIA ANTIGEN (CALLA) - IMPLICATIONS FOR MARROW TRANSPLANTATION
    KEATING, A
    WHALEN, CK
    SINGER, JW
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1983, 55 (04) : 623 - 628
  • [53] SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Kiel, MJ
    Yilmaz, ÖH
    Iwashita, T
    Yilmaz, OH
    Terhorst, C
    Morrison, SJ
    [J]. CELL, 2005, 121 (07) : 1109 - 1121
  • [54] Interleukin 7 regulates the survival and generation of memory CD4 cells
    Kondrack, RM
    Harbertson, J
    Tan, JT
    McBreen, ME
    Surh, CD
    Bradley, LM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) : 1797 - 1806
  • [55] Functional Heterogeneity of the Bone Marrow Vascular Niche
    Kopp, Hans-Georg
    Hooper, Andrea T.
    Avecilla, Scott T.
    Rafii, Shahin
    [J]. HEMATOPOIETIC STEM CELLS VII, 2009, 1176 : 47 - 54
  • [56] Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    Krampera, M
    Glennie, S
    Dyson, J
    Scott, D
    Laylor, R
    Simpson, E
    Dazzi, F
    [J]. BLOOD, 2003, 101 (09) : 3722 - 3729
  • [57] Bone marrow stromal cells: Characterization and clinical application
    Krebsbach, PH
    Kuznetsov, SA
    Bianco, P
    Robey, PG
    [J]. CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1999, 10 (02) : 165 - 181
  • [58] On T cell memory: Arguments for antigen dependence
    Kundig, TM
    Bachmann, MF
    Ohashi, PS
    Pircher, H
    Hengartner, H
    Zinkernagel, RM
    [J]. IMMUNOLOGICAL REVIEWS, 1996, 150 : 63 - 90
  • [59] IL-7 promotes the transition of CD4 effectors to persistent memory cells
    Li, JC
    Huston, G
    Swain, SL
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) : 1807 - 1815
  • [60] Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
    Link, Alexander
    Vogt, Tobias K.
    Favre, Stephanie
    Britschgi, Mirjam R.
    Acha-Orbea, Hans
    Hinz, Boris
    Cyster, Jason G.
    Luther, Sanjiv A.
    [J]. NATURE IMMUNOLOGY, 2007, 8 (11) : 1255 - 1265
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